Ohaegbulam Gail, Coats Laura E, Carlton Miller, Araji Sarah
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
Case Rep Womens Health. 2024 Mar 19;41:e00595. doi: 10.1016/j.crwh.2024.e00595. eCollection 2024 Mar.
Systemic lupus erythematosus is an autoimmune disease that primarily affects women of reproductive age. In pregnancy, it can lead to maternal and fetal complications. However, diagnosis in pregnancy is challenging since the disease mimics many features associated with other disorders and some complications related to pregnancy. Here we report a 24-year-old woman at 26 weeks gestation who presented with a fever of unknown origin. She developed tachycardia, nausea, fatigue, rigors, and pancytopenia. Once sepsis and other chronic conditions were ruled out, rheumatology was consulted. Following the diagnosis of systemic lupus erythematosus, a combination of hydroxychloroquine, azathioprine, and corticosteroids was started, and the patient showed rapid improvement. She had an uncomplicated delivery at term. This case report highlights a unique presentation of new-onset systemic lupus erythematous in pregnancy. Delay in diagnosis can lead to maternal and fetal complications; however, prompt diagnosis and treatment can improve symptoms and lead to a favorable pregnancy outcome.
系统性红斑狼疮是一种主要影响育龄女性的自身免疫性疾病。在怀孕期间，它可导致母婴并发症。然而，孕期诊断具有挑战性，因为该疾病具有许多与其他病症相关的特征以及一些与妊娠相关的并发症。在此，我们报告一名孕26周的24岁女性，她出现不明原因发热。她出现了心动过速、恶心、疲劳、寒战和全血细胞减少。排除败血症和其他慢性病后，咨询了风湿病科。诊断为系统性红斑狼疮后，开始使用羟氯喹、硫唑嘌呤和皮质类固醇联合治疗，患者病情迅速改善。她足月顺产，过程顺利。本病例报告突出了孕期新发系统性红斑狼疮的一种独特表现。诊断延迟可导致母婴并发症；然而，及时诊断和治疗可改善症状并带来良好的妊娠结局。
