Bostanci Seher, Aygun Alizada Merve, Farabi Banu, Akay Bengu Nisa
Dermatology and Venerology Department of Ankara University, Ankara, Turkey.
Dermatology Department of Mamak State Hospital, Ankara, Turkey.
Dermatol Pract Concept. 2024 Apr 1;14(2):e2024150. doi: 10.5826/dpc.1402a150.
Classic Kaposi's sarcoma (CKS) is a chronic and indolent skin tumor. Because CKS has a low mortality rate but can have a significant impact on quality of life, it is important to choose safe, long-term treatments with minimal side effects.
The aim was to assess the efficacy of long-pulsed Nd:YAG laser therapy in treating CKS based on clinical and dermoscopic observations.
Forty-two nodular lesions from three CKS patients (stage 4) were treated using a long-pulsed Nd:YAG laser with a spot size ranging from 3 to 7 mm, a fluence of 200-250 j/cm, and a pulse duration lasting between 10 and 20 milliseconds in one or two sessions. Patients were photographed clinically and dermoscopically before the procedure, immediately after the procedure, and at 1, 6, and 12 months after the procedure.
All participants displayed significant clinical and dermoscopic improvements, and all lesions healed within 2-3 weeks, resulting in only minor atrophic scars. No instance of recurrence was found among any of the patients during the 1-year follow-up.
Nd:YAG laser therapy may prove to be an effective therapeutic alternative for both early and advanced-stage CKS, specifically in instances of stubborn cutaneous lesions or patients receiving systemic therapy. The treatment results in quick improvement, typically within 2-3 weeks, and is well tolerated. Nd:YAG laser therapy could provide potential benefits for HIV-positive patients as it is free from immunosuppression, easy to apply to recurring lesions, and demonstrates overall effectiveness and safety.
经典型卡波西肉瘤（CKS）是一种慢性、惰性皮肤肿瘤。由于CKS死亡率低但会对生活质量产生重大影响，因此选择安全、副作用最小的长期治疗方法很重要。
旨在基于临床和皮肤镜观察评估长脉冲Nd:YAG激光治疗CKS的疗效。
对3例CKS患者（4期）的42个结节性病变采用长脉冲Nd:YAG激光进行治疗，光斑大小为3至7毫米，能量密度为200 - 250焦/平方厘米，脉冲持续时间为10至20毫秒，治疗1至2次。在治疗前、治疗后即刻以及治疗后1、6和12个月对患者进行临床和皮肤镜拍照。
所有参与者在临床和皮肤镜检查方面均有显著改善，所有病变在2至3周内愈合，仅留下轻微萎缩性瘢痕。在1年随访期间，所有患者均未出现复发情况。
Nd:YAG激光治疗可能是早期和晚期CKS的一种有效治疗选择，特别是对于顽固皮肤病变或接受全身治疗的患者。该治疗能在2至3周内迅速改善病情，耐受性良好。Nd:YAG激光治疗对HIV阳性患者可能具有潜在益处，因为它不会引起免疫抑制，易于应用于复发病变，且总体有效且安全。
