Faculty of Pharmacy, University of Montreal, Montréal, Québec, H3T 1J4, Canada.
Research Center of CHU Sainte-Justine, University of Montreal, Montréal, QC, H3T 1C5, Canada.
Adv Mater. 2024 Jun;36(25):e2401689. doi: 10.1002/adma.202401689. Epub 2024 Apr 8.
Bottlebrush polymers (BB) have emerged as compelling candidates for biosystems to face tribological challenges, including friction and wear. This study provides a comprehensive assessment of an engineered triblock BB polymer's affinity, cell toxicity, lubrication, and wear protection in both in vitro and in vivo settings, focusing on applications for conditions like osteoarthritis and dry eye syndrome. Results show that the designed polymer rapidly adheres to various surfaces (e.g., cartilage, eye, and contact lens), forming a robust, biocompatible layer for surface lubrication and protection. The tribological performance and biocompatibility are further enhanced in the presence of hyaluronic acid (HA) both in vitro and in vivo. The exceptional lubrication performance and favorable interaction with HA position the synthesized triblock polymer as a promising candidate for innovative treatments addressing deficiencies in bio-lubricant systems.
瓶刷聚合物 (BB) 已成为应对摩擦和磨损等摩擦学挑战的生物系统的有力候选者。本研究全面评估了一种工程化的三嵌段 BB 聚合物在体外和体内环境中的亲合力、细胞毒性、润滑性和磨损保护性能，重点关注骨关节炎和干眼症等疾病的应用。结果表明，设计的聚合物可快速附着在各种表面（如软骨、眼睛和隐形眼镜）上，形成一个用于表面润滑和保护的坚固、生物相容的层。体外和体内实验均表明，透明质酸 (HA) 的存在进一步增强了其摩擦学性能和生物相容性。该合成的三嵌段聚合物具有优异的润滑性能和与 HA 的良好相互作用，有望成为解决生物润滑系统缺陷的创新治疗方法的候选者。
