血清载脂蛋白 E 与中国颞叶癫痫患者认知功能的关系。

Association between serum apolipoprotein E and cognitive function in Chinese patients with temporal lobe epilepsy.

机构信息

Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning, 110016, China.

出版信息

Epilepsy Behav. 2024 May;154:109750. doi: 10.1016/j.yebeh.2024.109750. Epub 2024 Mar 28.

DOI:10.1016/j.yebeh.2024.109750

PMID:38552413

Abstract

OBJECTIVE

To investigate the effect of serum apolipoprotein E (APOE) levels on cognitive function in patients with temporal lobe epilepsy (TLE).

METHODS

Clinical data were collected from 190 subjects including 110 TLE patients and 80 healthy people. Cognitive function was assessed using the Addenbrooke's Cognitive Examination Revised (ACE-R) scale. Serum levels of APOE were measured using ELISA kits. Genotyping of APOE in peripheral blood was detected by microarray hybridization.

RESULTS

Patients with TLE had significantly lower ACE-R total score, memory and verbal fluency scores compared to the healthy group. Serum levels of APOE were significantly higher in TLE patients than in the healthy subjects. Serum APOE levels were significantly negatively correlated with ACE-R total score, memory and verbal fluency scores. The cognitive function score of TLE with APOE ε4 allele was lower than that of TLE without APOE ε4 allele.

SIGNIFICANCE

Our study showed that serum APOE levels were higher in TLE patients than in the healthy population. And serum APOE levels were associated with cognitive dysfunction in TLE patients. APOE ε4 allele carriers have poor cognitive function in TLE patients.

摘要

目的

探讨血清载脂蛋白 E（APOE）水平对颞叶癫痫（TLE）患者认知功能的影响。

方法

收集了 190 名受试者的临床资料，包括 110 名 TLE 患者和 80 名健康人。采用 Addenbrooke 认知测验修订版（ACE-R）量表评估认知功能。采用 ELISA 试剂盒检测血清 APOE 水平。采用微阵列杂交法检测外周血 APOE 基因型。

结果

TLE 患者的 ACE-R 总分、记忆和言语流畅性评分明显低于健康组。TLE 患者的血清 APOE 水平明显高于健康受试者。血清 APOE 水平与 ACE-R 总分、记忆和言语流畅性评分呈显著负相关。携带 APOE ε4 等位基因的 TLE 患者认知功能评分低于不携带 APOE ε4 等位基因的 TLE 患者。