Department of Obstetrics and Gynecology, the First Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China.
College of Medicine, Nankai University, 94 Weijin Road, Tianjin, China.
J Int Med Res. 2024 Mar;52(3):3000605241233966. doi: 10.1177/03000605241233966.
This retrospective study investigated the effects of uterine manipulator use during minimally invasive radical hysterectomy on prognosis in patients with cervical cancer.
We collected clinical data on 762 patients with stage IA2 to IIB cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy in Chinese PLA General Hospital from 2009 to 2019. Kaplan-Meier analysis and log-rank tests were used to compare the 5-year overall survival rates between patients treated with and without a uterine manipulator.
Patient demographics did not differ between the two groups. In addition, the incidence of lymphovascular space invasion, tumor size, pathologic types, the International Federation of Gynecology and Obstetrics stage, the histologic grade, and the rate of lymphatic metastases did not differ between the groups. Meanwhile, perioperative clinical indicators were similar in the groups. Furthermore, no significant differences in 5-year survival rates and survival curves were recorded between the groups among both all patients (84.5% vs. 85.6%) and early-stage patients (89.1% vs. 89.2%).
The use of uterine manipulators during minimally invasive radical hysterectomy for cervical cancer did not affect clinicopathological markers or increase the risk of death.
本回顾性研究旨在探讨在微创根治性子宫切除术期间使用子宫操纵器对宫颈癌患者预后的影响。
我们收集了 2009 年至 2019 年期间在中国人民解放军总医院接受根治性子宫切除术和盆腔淋巴结切除术的 762 例 IA2 期至 IIB 期宫颈癌患者的临床数据。采用 Kaplan-Meier 分析和对数秩检验比较了使用和不使用子宫操纵器的两组患者的 5 年总生存率。
两组患者的人口统计学特征无差异。此外，两组的脉管间隙浸润发生率、肿瘤大小、病理类型、国际妇产科联合会分期、组织学分级和淋巴转移率均无差异。同时，两组的围手术期临床指标相似。此外，两组患者的 5 年生存率和生存曲线均无显著差异，包括所有患者（84.5% vs. 85.6%）和早期患者（89.1% vs. 89.2%）。
在微创根治性子宫切除术期间使用子宫操纵器不会影响宫颈癌的临床病理标志物，也不会增加死亡风险。
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