Zhuhai Hospital of Traditional Chinese and Western Medicine, Zhuhai City, Guangdong, People's Republic of China.
State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, People's Republic of China.
BMC Cancer. 2021 May 10;21(1):531. doi: 10.1186/s12885-021-08243-3.
Cervical cancer continues to be one of the leading causes of cancer deaths among females in low and middle-income countries. In this study, we aimed to assess the independent prognostic value of clinical and potential prognostic factors in progression-free survival (PFS) in cervical cancer.
We conducted a retrospective study on 92 cervical cancer patients treated from 2017 to 2019 at the Zhuhai Hospital of Traditional Chinese and Western Medicine. Tumor characteristics, treatment options, progression-free survival and follow-up information were collected. Kaplan-Meier method was used to assess the PFS.
Results showed that the number of retrieved lymph nodes had a statistically significant effect on PFS of cervical cancer patients (P = 0.002). Kaplan-Meier survival curve analysis showed that cervical cancer patients with initial symptoms age 25-39 had worse survival prognoses (P = 0.020). And the using of uterine manipulator in laparoscopic treatment showed a better prognosis (P < 0.001). A novel discovery of our study was to verify the prognostic values of retrieved lymph nodes count combining with FIGO staging system, which had never been investigated in cervical cancer before. According to the Kaplan-Meier survival curve analysis and receiver operating characteristic (ROC) curve analysis, significant improvements were found after the combination of retrieved lymph nodes count and FIGO stage in predicting PFS for cervical cancer patients (P < 0.001, AUC = 0.826, 95% CI: 0.689-0.962).
Number of retrieved lymph nodes, initial symptoms age, uterine manipulator, and retrieved lymph nodes count combining with FIGO staging system could be potential prognostic factors for cervical cancer patients.
宫颈癌仍然是中低收入国家女性癌症死亡的主要原因之一。在本研究中，我们旨在评估临床和潜在预后因素对宫颈癌无进展生存期（PFS）的独立预后价值。
我们对 2017 年至 2019 年在珠海市中西医结合医院接受治疗的 92 例宫颈癌患者进行了回顾性研究。收集了肿瘤特征、治疗选择、无进展生存和随访信息。Kaplan-Meier 法用于评估 PFS。
结果表明，检出的淋巴结数量对宫颈癌患者的 PFS 有统计学显著影响（P=0.002）。Kaplan-Meier 生存曲线分析显示，25-39 岁初诊症状的宫颈癌患者生存预后较差（P=0.020）。腹腔镜治疗中使用子宫操纵器显示出更好的预后（P<0.001）。我们的研究的一个新发现是验证了检出的淋巴结数量与 FIGO 分期系统相结合的预后价值，这在宫颈癌中以前从未被研究过。根据 Kaplan-Meier 生存曲线分析和受试者工作特征（ROC）曲线分析，在预测宫颈癌患者 PFS 方面，检出的淋巴结数量和 FIGO 分期的结合后显著改善（P<0.001，AUC=0.826，95%CI：0.689-0.962）。
检出的淋巴结数量、初诊症状年龄、子宫操纵器以及检出的淋巴结数量与 FIGO 分期系统的结合可以成为宫颈癌患者的潜在预后因素。
