Barabas G, Matthews W S
Pediatrics. 1985 Jan;75(1):73-5.
The existence of two clinically homogeneous subgroups in Tourette syndrome, depending upon the presence or absence of migraine or a family history of migraine, is suggested. Patients with Tourette syndrome who have migraine (n = 18) were found to have a significantly higher prevalence of disorders of arousal--particularly sleepwalking and night terrors--as well as a higher prevalence of motion sickness than patients without migraine (n = 27). They were also significantly more likely to exhibit a co-occurrence of associated features (two or more) than the patients without migraine. Patients with Tourette syndrome who have not had migraine headaches but in whom there is a family history for migraine (n = 20) were shown to have an intermediate prevalence of associated symptoms. It is suggested that the differential association for these symptoms in patients with Tourette syndrome may reflect an underlying abnormality in function of two different neurotransmitter systems.
有迹象表明，抽动秽语综合征存在两个临床特征相同的亚组，这取决于偏头痛的有无或偏头痛家族史。研究发现，患有偏头痛的抽动秽语综合征患者（n = 18）与无偏头痛的患者（n = 27）相比，觉醒障碍——尤其是梦游和夜惊——的患病率显著更高，晕动病的患病率也更高。他们同时出现相关特征（两种或更多）的可能性也显著高于无偏头痛的患者。没有偏头痛病史但有偏头痛家族史的抽动秽语综合征患者（n = 20）的相关症状患病率处于中等水平。有迹象表明，抽动秽语综合征患者这些症状的差异关联可能反映了两种不同神经递质系统功能的潜在异常。
