The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, Liaoning, China.
Commun Biol. 2024 Mar 29;7(1):382. doi: 10.1038/s42003-024-06080-1.
Autophagy is a dynamic self-renovation biological process that maintains cell homeostasis and is responsible for the quality control of proteins, organelles, and energy metabolism. The E1-like ubiquitin-activating enzyme autophagy-related gene 7 (ATG7) is a critical factor that initiates classic autophagy reactions by promoting the formation and extension of autophagosome membranes. Recent studies have identified the key functions of ATG7 in regulating the cell cycle, apoptosis, and metabolism associated with the occurrence and development of multiple diseases. This review summarizes how ATG7 is precisely programmed by genetic, transcriptional, and epigenetic modifications in cells and the relationship between ATG7 and aging-related diseases.
自噬是一种动态的自我修复的生物学过程，可维持细胞内环境稳定，并负责蛋白质、细胞器和能量代谢的质量控制。E1 样泛素激活酶自噬相关基因 7（ATG7）是通过促进自噬体膜的形成和延伸来启动经典自噬反应的关键因素。最近的研究已经确定了 ATG7 在调节细胞周期、凋亡以及与多种疾病的发生和发展相关的代谢中的关键功能。本综述总结了 ATG7 如何在细胞中通过遗传、转录和表观遗传修饰来精确编程，以及 ATG7 与衰老相关疾病的关系。
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