哺乳动物大脑的部分重编程
Partial reprogramming of the mammalian brain.
作者信息
Asmussen Niels C, Schafer Marissa J
机构信息
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
出版信息
Nat Aging. 2024 Apr;4(4):440-442. doi: 10.1038/s43587-024-00596-1.
Abstract
Xu and colleagues used partial OSKM reprogramming in aged mice to drive cell-type proportions of the subventricular zone to more youthful levels, which equates to qualified rejuvenation of a neurogenic niche that is defined, in part, by restoration of neuroblast levels.
摘要
徐及其同事在老年小鼠中使用部分OSKM重编程，将脑室下区的细胞类型比例驱动至更年轻的水平，这等同于对神经源性微环境进行了有条件的年轻化，部分定义为神经母细胞水平的恢复。
相似文献
1
Partial reprogramming of the mammalian brain.哺乳动物大脑的部分重编程
Nat Aging. 2024 Apr;4(4):440-442. doi: 10.1038/s43587-024-00596-1.
2
Epigenetic reprogramming in the mammalian germline.哺乳动物种系中的表观遗传重编程。
Oncotarget. 2015 Nov 3;6(34):35151-2. doi: 10.18632/oncotarget.6206.
3
Diverse partial reprogramming strategies restore youthful gene expression and transiently suppress cell identity.多种部分重编程策略可恢复年轻的基因表达，并暂时抑制细胞身份。
Cell Syst. 2022 Jul 20;13(7):574-587.e11. doi: 10.1016/j.cels.2022.05.002. Epub 2022 Jun 10.
4
Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin.体外细胞重编程和体内组织再生的中间细胞需要桥粒斑蛋白。
Sci Adv. 2022 Oct 28;8(43):eabk1239. doi: 10.1126/sciadv.abk1239.
5
Epigenome in Early Mammalian Development: Inheritance, Reprogramming and Establishment.早期哺乳动物发育中的表观基因组：遗传、重编程和建立。
Trends Cell Biol. 2018 Mar;28(3):237-253. doi: 10.1016/j.tcb.2017.10.008. Epub 2017 Dec 5.
6
[Mammalian DNA methylation and its roles during the induced re-programming of somatic cells].[哺乳动物DNA甲基化及其在体细胞诱导重编程过程中的作用]
Yi Chuan. 2014 May;36(5):431-8.
7
Primordial germ-cell development and epigenetic reprogramming in mammals.哺乳动物原始生殖细胞的发育与表观遗传重编程
Curr Top Dev Biol. 2013;104:149-87. doi: 10.1016/B978-0-12-416027-9.00005-X.
8
Mechanisms of cellular rejuvenation.细胞再生活跃的机制。
FEBS Lett. 2019 Dec;593(23):3381-3392. doi: 10.1002/1873-3468.13483. Epub 2019 Jun 24.
9
Epigenetic reprogramming--taking a lesson from the embryo.表观遗传重编程——从胚胎中吸取教训。
Curr Opin Cell Biol. 2010 Jun;22(3):342-50. doi: 10.1016/j.ceb.2010.04.011. Epub 2010 May 27.
10
Partial cellular reprogramming: A deep dive into an emerging rejuvenation technology.部分细胞重编程：新兴的抗衰老技术深度剖析。
Aging Cell. 2024 Feb;23(2):e14039. doi: 10.1111/acel.14039. Epub 2023 Dec 1.
本文引用的文献
1
Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism.年轻血浆来源的小细胞外囊泡通过改善线粒体能量代谢逆转与年龄相关的功能衰退。
Nat Aging. 2024 Jun;4(6):814-838. doi: 10.1038/s43587-024-00612-4. Epub 2024 Apr 16.
2
In vivo reprogramming leads to premature death linked to hepatic and intestinal failure.体内重编程导致与肝和肠衰竭相关的过早死亡。
Nat Aging. 2023 Dec;3(12):1509-1520. doi: 10.1038/s43587-023-00528-5. Epub 2023 Nov 27.
3
Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain.细胞类型特异性衰老时钟，用于量化大脑神经发生区域的衰老和年轻化。
Nat Aging. 2023 Jan;3(1):121-137. doi: 10.1038/s43587-022-00335-4. Epub 2022 Dec 19.
4
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice.在体内进行部分重编程可改变小鼠生理衰老过程中与年龄相关的分子变化。
Nat Aging. 2022 Mar;2(3):243-253. doi: 10.1038/s43587-022-00183-2. Epub 2022 Mar 7.
5
Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age.衰老时钟与死亡率定时器、甲基化、糖组学、端粒等。一扇测量生物学年龄的窗口。
Aging Med (Milton). 2022 Feb 5;5(2):120-125. doi: 10.1002/agm2.12197. eCollection 2022 Jun.
6
Direct cell reprogramming: approaches, mechanisms and progress.直接细胞重编程：方法、机制与进展。
Nat Rev Mol Cell Biol. 2021 Jun;22(6):410-424. doi: 10.1038/s41580-021-00335-z. Epub 2021 Feb 22.
7
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.体内重编程改善齿状回细胞的衰老特征，并改善小鼠的记忆。
Stem Cell Reports. 2020 Nov 10;15(5):1056-1066. doi: 10.1016/j.stemcr.2020.09.010. Epub 2020 Oct 22.
8
Mechanisms of enhanced quiescence in neural stem cell aging.神经干细胞衰老中增强的静止机制。
Mech Ageing Dev. 2020 Oct;191:111323. doi: 10.1016/j.mad.2020.111323. Epub 2020 Aug 8.
9
Rejuvenating subventricular zone neurogenesis in the aging brain.衰老大脑中的侧脑室下区神经发生的再生。
Curr Opin Pharmacol. 2020 Feb;50:1-8. doi: 10.1016/j.coph.2019.10.005. Epub 2019 Nov 19.
10
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.通过部分重编程在体内改善与年龄相关的特征
Cell. 2016 Dec 15;167(7):1719-1733.e12. doi: 10.1016/j.cell.2016.11.052.
Zotero 插件