Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Department of Pediatrics, Scarborough Health Network, Toronto, Ontario, Canada.
J Perinatol. 2024 Jun;44(6):880-885. doi: 10.1038/s41372-024-01946-y. Epub 2024 Mar 29.
To compare neurodevelopmental outcomes at 18-24 months corrected age (CA) for preterm infants who had hemoglobin levels <120 g/l versus those with hemoglobin level ≥120 g/l at birth.
We included infants of ≤28 weeks gestational age (GA) born between January 2009 and June 2018. The primary outcome was neurodevelopmental impairment (NDI) at 18-24 months. Multivariable logistic regression was applied to determine the association.
Of the 2351 eligible neonates, 351 (14.9%) had hemoglobin levels <120 g/L at birth. Of the 2113 surviving infants, 1534 (72.5%) underwent developmental follow-up at 18-24 months CA. There was no statistically significant difference in ND outcomes between the two groups. The composite outcome of death or NDI was significantly higher in the low hemoglobin group.
In preterm infants ≤28 weeks GA, initial hemoglobin <120 g/L at birth was not associated with neurodevelopmental impairment at 18-24 months CA among survivors.
比较出生时血红蛋白水平<120g/l与血红蛋白水平≥120g/l的早产儿在 18-24 个月校正年龄（CA）时的神经发育结局。
我们纳入了 2009 年 1 月至 2018 年 6 月间出生、胎龄（GA）≤28 周的婴儿。主要结局为 18-24 个月时的神经发育障碍（NDI）。采用多变量逻辑回归来确定相关性。
在 2351 名符合条件的新生儿中，有 351 名（14.9%）出生时血红蛋白水平<120g/L。在 2113 名存活婴儿中，有 1534 名（72.5%）在 18-24 个月 CA 时进行了发育随访。两组之间的 NDI 结局无统计学差异。低血红蛋白组的死亡或 NDI 复合结局显著更高。
在胎龄≤28 周的早产儿中，出生时初始血红蛋白<120g/L与存活者在 18-24 个月 CA 时的神经发育障碍无关。
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