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宫颈环扎术对孕妇阴道微生物群及其代谢产物的影响。

The effects of cervical cerclage on the vaginal microbiota and its metabolites in pregnant women.

作者信息

Zhang Jun, Wang Lihua, Zhang Mengjun, Xu Zhimin, Zheng Yijing, Lv Bingqing, Pan Mian

机构信息

Department of Obstetrics & Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.

出版信息

Front Cell Infect Microbiol. 2025 Jun 16;15:1577947. doi: 10.3389/fcimb.2025.1577947. eCollection 2025.

DOI:10.3389/fcimb.2025.1577947
PMID:40589865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12206701/
Abstract

Cervical cerclage is widely used to reduce the risk of preterm birth in pregnant women. The effects of cervical cerclage on the vaginal microbiota and its metabolites are not fully clear. The purpose of this study was to explore the influence of cervical cerclage on the vaginal microbiota and its metabolites. Our results showed that the clinical characteristics [white blood cell (WBC), neutrophil, lymphocyte, monocytes, platelet, NLR, PLR, SII, SIRI, and C-reactive protein (CRP)] and α-diversity (Observed, Shannon, Chao1, and Simpson indexes) of the vaginal microbiota were not altered during pregnancy after cervical cerclage. 16S rRNA gene sequencing found that the relative abundance of and was significantly increased in the post-cerclage group compared with the pre-cerclage group, but the relative abundance of was significantly reduced. In addition, the volcano plot revealed that a total of 19 metabolites [including alpha-hydroxyalprazolam, LPE (18:1(9Z)/0:0), PS(16:0/15:0), -acetylhistamine, carnitine, pseudouridine, and allopregnanolone] were significantly changed during pregnancy after cervical cerclage. Pathway analysis based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database showed that the changes in the vaginal microbiota and its metabolites mainly involved purine metabolism and amino acid metabolism. The alteration in the vaginal microbiota and its metabolites induced by cervical cerclage is associated with the therapeutic efficacy of cervical cerclage. Further studies are needed to explore how the vaginal microbiota affects the outcomes of pregnancy.

摘要

宫颈环扎术被广泛用于降低孕妇早产风险。宫颈环扎术对阴道微生物群及其代谢产物的影响尚不完全清楚。本研究的目的是探讨宫颈环扎术对阴道微生物群及其代谢产物的影响。我们的结果表明，宫颈环扎术后孕期阴道微生物群的临床特征[白细胞（WBC）、中性粒细胞、淋巴细胞、单核细胞、血小板、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、全身免疫炎症指数（SII）、全身感染反应指数（SIRI）和C反应蛋白（CRP）]以及α多样性（观察值、香农指数、Chao1指数和辛普森指数）未发生改变。16S rRNA基因测序发现，与环扎术前组相比，环扎术后组 和 的相对丰度显著增加，但 的相对丰度显著降低。此外，火山图显示，宫颈环扎术后孕期共有19种代谢产物[包括α-羟基阿普唑仑、溶血磷脂酰乙醇胺（LPE，18:1(9Z)/0:0）、磷脂酰丝氨酸（PS，16:0/15:0）、N-乙酰组胺、肉碱、假尿苷和别孕烯醇酮]发生了显著变化。基于京都基因与基因组百科全书（KEGG）数据库的通路分析表明，阴道微生物群及其代谢产物的变化主要涉及嘌呤代谢和氨基酸代谢。宫颈环扎术引起的阴道微生物群及其代谢产物的改变与宫颈环扎术的治疗效果相关。需要进一步研究以探索阴道微生物群如何影响妊娠结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/141e5e8c8e49/fcimb-15-1577947-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/5d6dbc42b846/fcimb-15-1577947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/5a7e60ffe8dd/fcimb-15-1577947-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/4d4cb2eb963d/fcimb-15-1577947-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/e8c489a19dc1/fcimb-15-1577947-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/a5e68635a80e/fcimb-15-1577947-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/141e5e8c8e49/fcimb-15-1577947-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/5d6dbc42b846/fcimb-15-1577947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/5a7e60ffe8dd/fcimb-15-1577947-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/4d4cb2eb963d/fcimb-15-1577947-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/e8c489a19dc1/fcimb-15-1577947-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/a5e68635a80e/fcimb-15-1577947-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c3/12206701/141e5e8c8e49/fcimb-15-1577947-g006.jpg

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