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探讨外泌体与免疫肿瘤微环境之间的动态相互作用:对乳腺癌进展和治疗策略的影响。

Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies.

机构信息

Immunology Research Center, Tabriz University of Medical Sciences, Gholghasht Ave, Tabriz, Iran.

Department of Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

出版信息

Breast Cancer Res. 2024 Mar 29;26(1):57. doi: 10.1186/s13058-024-01810-z.

Abstract

Breast cancer continues to pose a substantial worldwide health concern, demanding a thorough comprehension of the complex interaction between cancerous cells and the immune system. Recent studies have shown the significant function of exosomes in facilitating intercellular communication and their participation in the advancement of cancer. Tumor-derived exosomes have been identified as significant regulators in the context of breast cancer, playing a crucial role in modulating immune cell activity and contributing to the advancement of the illness. This study aims to investigate the many effects of tumor-derived exosomes on immune cells in the setting of breast cancer. Specifically, we will examine their role in influencing immune cell polarization, facilitating immunological evasion, and modifying the tumor microenvironment. Furthermore, we explore the nascent domain of exosomes produced from immune cells and their prospective involvement in the prevention of breast cancer. This paper focuses on new research that emphasizes the immunomodulatory characteristics of exosomes produced from immune cells. It also explores the possibility of these exosomes as therapeutic agents or biomarkers for the early identification and prevention of breast cancer. The exploration of the reciprocal connections between exosomes formed from tumors and immune cells, together with the rising significance of exosomes derived from immune cells, presents a potential avenue for the advancement of novel approaches in the field of breast cancer therapy and prevention.

摘要

乳腺癌仍然是一个全球性的重大健康问题,需要深入理解癌细胞和免疫系统之间的复杂相互作用。最近的研究表明,外泌体在促进细胞间通讯方面具有重要功能,并且它们参与了癌症的进展。肿瘤衍生的外泌体已被确定为乳腺癌背景下的重要调节因子,在外泌体在调节免疫细胞活性和促进疾病进展方面起着至关重要的作用。本研究旨在探讨肿瘤衍生的外泌体在乳腺癌中对免疫细胞的多种影响。具体来说,我们将研究它们在影响免疫细胞极化、促进免疫逃逸以及改变肿瘤微环境方面的作用。此外,我们还探讨了免疫细胞产生的外泌体的新兴领域及其在预防乳腺癌方面的潜在作用。本文重点介绍了强调免疫细胞来源的外泌体免疫调节特性的新研究。它还探讨了这些外泌体作为治疗剂或生物标志物用于早期识别和预防乳腺癌的可能性。探索肿瘤和免疫细胞来源的外泌体之间的相互联系,以及免疫细胞来源的外泌体的重要性日益增加,为乳腺癌治疗和预防领域的新方法的发展提供了潜在途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fce/10981336/9f6062a2fdb4/13058_2024_1810_Fig1_HTML.jpg

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