Department of Radiation Oncology, Amrita School of Medicine, Amrita Vishwa Vidyapeetham, AIMS Ponekkara P.O, Kochi, Kerala, India.
J Cancer Res Ther. 2024 Jan 1;20(1):493-495. doi: 10.4103/jcrt.JCRT_1640_20. Epub 2023 Sep 21.
Extramedullary plasmacytoma of the larynx is an extremely rare entity accounting for 0.04-0.45% of malignant tumours of the larynx. The objective of this clinical case report is to highlight the diagnosis and management of a unique case such as this. A 77-year-old gentleman presented with complaints of hoarseness for 1 year. Computed tomography image revealed a soft tissue mass lesion involving the right true vocal cord. Direct laryngoscopic biopsy was performed and subjected to histopathological examination, which showed collection of plasma cells. Immunohistochemistry confirmed the presence of Kappa and Lambda cells. Multiple myeloma (MM) was ruled out. The patient received radical intent radiation therapy using 3DCRT technique with a dose of 50Gy in 25# over 5 weeks. He experienced improvement in hoarseness on subsequent follow-up visits. At 1-year follow up, positron emission tomography computed tomography showed near total resolution of disease with no progression to MM. Radiation therapy alone is known to achieve good local control, recurrence free survival, and organ preservation in such cases.
喉外浆细胞瘤极为罕见，占喉部恶性肿瘤的 0.04%-0.45%。本临床病例报告的目的是突出此类独特病例的诊断和处理。一名 77 岁男性因声嘶 1 年就诊。计算机断层扫描图像显示累及右侧真声带的软组织肿块病变。行直接喉镜活检，并进行组织病理学检查，显示浆细胞聚集。免疫组化证实 Kappa 和 Lambda 细胞存在。排除多发性骨髓瘤（MM）。患者接受了根治性意向放射治疗，采用 3DCRT 技术，5 周内共 25 次给予 50Gy 的剂量。在随后的随访中，他的声音嘶哑有所改善。1 年随访时，正电子发射断层扫描计算机断层扫描显示疾病几乎完全缓解，无进展为 MM。单独放疗在这种情况下已知可实现良好的局部控制、无复发生存和器官保存。
