Shklar G, Niukian K, Hassan M, Herbosa E G
J Oral Maxillofac Surg. 1985 Feb;43(2):80-6. doi: 10.1016/0278-2391(85)90053-9.
The effects of smokeless tobacco on oral mucosa were studied in 60 Syrian hamsters. Histologic study of the buccal pouch mucosa revealed no significant pathologic changes at either ten or 20 weeks after the start of the experiment. However, studies on epithelial whole mounts revealed a statistically significant decrease in mitotic activity and a statistically significant increase in the number of Langerhans' cells in animals subjected to daily use of tobacco or snuff for 20 weeks.
在60只叙利亚仓鼠身上研究了无烟烟草对口腔黏膜的影响。对颊囊黏膜的组织学研究显示，实验开始后10周和20周时均未发现明显的病理变化。然而，对上皮全层铺片的研究显示，在每天使用烟草或鼻烟20周的动物中，有丝分裂活性有统计学意义的下降，朗格汉斯细胞数量有统计学意义的增加。
