Schwartz J L, Weichselbaum R, Frim S R
Exp Gerontol. 1983;18(1):65-71. doi: 10.1016/0531-5565(83)90052-9.
Previous studies localizing the Langerhans cells in the hamster cheek pouch by ATPase staining have shown these cells to be distributed in a nonrandom pattern. The Langerhans cells have been found in both focal and interfocal arrangements. In this study we utilized two groups, Group 1 (six animals), was 5-6 weeks old, and Group 2 (six animals), was 78-80 weeks old. The Langerhans cells were stained for ATPase, following the epidermal stripping of the cheek pouch with 1% glacial acetic acid. The number of Langerhans was statistically decreased interfocally and there was a decrease in the number of focal aggregations, while there was a concomitant increase in the number of Langerhans cells in each unit. These alterations in the density and distribution of the Langerhans cells may suggest a lowering of the immune response, and increase susceptibility to irritants and carcinogenic agents in the oral cavity.
以往通过ATP酶染色对仓鼠颊囊内朗格汉斯细胞进行定位的研究表明，这些细胞呈非随机分布。已发现朗格汉斯细胞呈局灶性和局灶间排列。在本研究中，我们使用了两组动物，第1组（6只动物），年龄为5 - 6周，第2组（6只动物），年龄为78 - 80周。在用1%冰醋酸对颊囊进行表皮剥脱后，对朗格汉斯细胞进行ATP酶染色。局灶间朗格汉斯细胞数量在统计学上减少，局灶性聚集数量减少，而每个单位内朗格汉斯细胞数量相应增加。朗格汉斯细胞密度和分布的这些变化可能表明免疫反应降低，以及口腔对刺激物和致癌剂的易感性增加。
