Department of Dermatological, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610036, China.
Department of Dermatological, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610036, China.
Fitoterapia. 2024 Jun;175:105918. doi: 10.1016/j.fitote.2024.105918. Epub 2024 Mar 28.
Keloids are prevalent pathological scars, often leading to cosmetic deformities and hindering joint mobility.They cause discomfort, including burning and itching, while gradually expanding and potentially posing a risk of cancer.Developing effective drugs and treatments for keloids has been a persistent challenge in the medical field. Natural products are an important source of innovative drugs and a breakthrough for many knotty disease.Herein, keywords of "natural, plant, compound, extract" were combined with "keloid" and searched in PubMed and Google Scholar, respectively. A total of 32 natural products as well as 9 extracts possessing the potential for treating keloids were ultimately identified.Current research in this field faces a significant challenge due to the lack of suitable animal models, resulting in a predominant reliance on in vitro studies.In vivo and clinical studies are notably scarce as a result.Moreover, there is a notable deficiency in research focusing on the role of nutrients in keloid formation and treatment.The appropriate dosage form (oral, topical, injectable) is crucial for the development of natural product drugs. Finally, the conclusion was hereby made that natural products, when used as adjuncts to other treatments, hold significant potential in the management of keloids.By summarizing the natural products and elucidating their mechanisms in keloid treatment, the present study aims to stimulate further discoveries and research in drug development for effectively addressing this challenging condition.
瘢痕疙瘩是一种常见的病理性瘢痕，常导致美容畸形和关节活动受限。它们引起不适，包括烧灼感和瘙痒感，同时逐渐扩大，并可能有致癌风险。开发有效的瘢痕疙瘩治疗药物一直是医学领域的一个持续挑战。天然产物是创新药物的重要来源，也是许多棘手疾病的突破点。在此，我们在 PubMed 和 Google Scholar 中分别使用“天然、植物、化合物、提取物”等关键词与“瘢痕疙瘩”进行组合搜索，共鉴定出 32 种具有治疗瘢痕疙瘩潜力的天然产物和 9 种提取物。目前，由于缺乏合适的动物模型，该领域的研究主要依赖于体外研究，体内和临床研究明显较少。此外，研究重点主要集中在营养素在瘢痕疙瘩形成和治疗中的作用上，这方面的研究明显不足。对于天然产物药物的开发，合适的剂型（口服、局部、注射）至关重要。最后得出结论，天然产物作为其他治疗方法的辅助手段，在瘢痕疙瘩的治疗中具有很大的潜力。通过总结天然产物及其在瘢痕疙瘩治疗中的作用机制，本研究旨在促进药物开发方面的进一步发现和研究，以有效应对这一具有挑战性的疾病。
