Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium; Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium; Brain Stimulation and Cognition (BSC) Lab, Department of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, The Netherlands.
Tübingen Center for Mental Health (TüCMH), Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany.
Clin Neurophysiol. 2024 Jun;162:235-247. doi: 10.1016/j.clinph.2024.03.016. Epub 2024 Mar 19.
Previous studies suggest that theta burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (rTMS), applied to the left dorsolateral prefrontal cortex (DLPFC) might be a promising approach to modulate stress-reactive rumination and the associated psychophysiological stress response. Crucially, individuals showing higher levels of trait rumination might benefit more from prefrontal stimulation.
In this sham-controlled study, 127 healthy individuals, with varying ruminative tendencies, received a single-session of intermittent TBS (iTBS), continuous TBS (cTBS) or sham TBS (sTBS) over the left DLPFC before being confronted with a Trier Social Stress Test.
Results showed significant TBS effects on salivary cortisol as a function of trait rumination. cTBS, as compared to sTBS and iTBS, resulted in an attenuated stress-induced cortisol response in high compared to low trait ruminators. Although independent of trait rumination levels, cTBS showed positive effects on stress-related changes in mood and, both cTBS and iTBS (versus sham) presented an enhanced heart rate recovery following the stressor. We found no evidence for (trait rumination-dependent) TBS effects on stress-reactive rumination, negative affect, subjective stress or heart rate variability.
cTBS shows beneficial effects on certain measures of stress, especially in high trait ruminators.
These findings highlight the importance of accounting for individual differences when examining TBS effects.
先前的研究表明，经颅磁刺激（rTMS）中的θ爆发刺激（TBS）作用于左侧背外侧前额皮质（DLPFC）可能是调节应激反应性反刍和相关心理生理应激反应的一种有前途的方法。至关重要的是，表现出更高特质反刍倾向的个体可能会从前额叶刺激中获益更多。
在这项假对照研究中，127 名具有不同反刍倾向的健康个体在接受左侧 DLPFC 的单次间歇性 TBS（iTBS）、连续 TBS（cTBS）或假 TBS（sTBS）治疗后，接受了特里尔社会应激测试。
结果表明，TBS 对唾液皮质醇具有显著的影响，这与特质反刍有关。与 sTBS 和 iTBS 相比，cTBS 导致高特质反刍者的皮质醇应激反应减弱，而低特质反刍者则没有。尽管 cTBS 不受特质反刍水平的影响，但它对与压力相关的情绪变化有积极影响，cTBS 和 iTBS（与假刺激相比）在应激后心率恢复增强。我们没有发现 TBS 对应激反应性反刍、负性情绪、主观压力或心率变异性的（特质反刍依赖）效应的证据。
cTBS 对某些应激指标有有益的影响，尤其是对高特质反刍者。
这些发现强调了在检查 TBS 效应时考虑个体差异的重要性。
