Lemoine F, Najman A, Laporte J P, Gorin N C, Duhamel G
Cancer Treat Rep. 1985 Feb;69(2):203-4.
Eight patients with chronic myeloid leukemia in blast crisis were treated with a combination of vindesine and prednisone. Complete remission was achieved in three patients; partial remission was achieved in three. All six responders received maintenance treatment with hydroxyurea and 6-mercaptopurine. The median duration of survival was 9 months. Two patients had long-term survival: one survived 32 months and the other is alive after 30 months. These data suggest that vindesine-prednisone polychemotherapy might improve the prognosis of blast crisis in chronic myeloid leukemia.
八例慢性粒细胞白血病急变期患者接受了长春地辛与泼尼松联合治疗。三名患者获得完全缓解；三名患者获得部分缓解。所有六名有反应的患者均接受了羟基脲和6-巯基嘌呤维持治疗。中位生存期为9个月。两名患者长期存活：一名存活32个月，另一名在30个月后仍存活。这些数据表明，长春地辛-泼尼松联合化疗可能改善慢性粒细胞白血病急变期的预后。
