Uzuka Y, Saito Y, Takahash H, Komatsu M
Gan To Kagaku Ryoho. 1984 May;11(5):1064-70.
Twenty patients with chronic myelogenous leukemia in terminal transformation were treated with regimen incorporating vindesine, prednisolone and additional cytosine arabinoside. Of the 19 patients in blastic crisis, complete remission was achieved in 13 (68.4%). All four patients with lymphoid morphology, and nine of the eleven patients with myeloid morphology, achieved complete remission (81.8%); the four with monocytoid morphology did not. One patient in accelerated phase also attained complete remission. The present results indicate that the regimen incorporating vindesine-cytosine arabinoside-prednisolone should be treatment of choice in CML-BC with lymphoid morphology and myeloid morphology as well.
对20例处于终末期转化的慢性粒细胞白血病患者采用包含长春地辛、泼尼松龙及额外阿糖胞苷的方案进行治疗。在19例处于急变期的患者中，13例（68.4%）实现了完全缓解。所有4例具有淋巴细胞形态的患者以及11例具有髓细胞形态的患者中的9例（81.8%）实现了完全缓解；4例具有单核细胞形态的患者未实现完全缓解。1例处于加速期的患者也实现了完全缓解。目前的结果表明，包含长春地辛-阿糖胞苷-泼尼松龙的方案也应成为具有淋巴细胞形态和髓细胞形态的慢性粒细胞白血病急变期的首选治疗方案。
