Department of Dermatology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong 518020, China.
Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen, Guangdong 518020, China.
ACS Appl Mater Interfaces. 2024 Apr 10;16(14):17080-17091. doi: 10.1021/acsami.3c17091. Epub 2024 Apr 1.
Psoriasis is a systemic, recurrent, chronic autoimmune skin disease. However, psoriasis drugs have poor skin permeability and high toxicity, resulting in low bioavailability and affecting their clinical application. In this study, we propose a curcumin-based ionic liquid hydrogel loaded with ilomastat (Cur-Car-IL@Ilo hydrogel), which can effectively maintain the sustained release of drugs and improve the skin permeability of drugs. We used a model of imiquimod-induced psoriasis and demonstrated that local application of Cur-Car-IL@Ilo hydrogel can improve skin lesions in mice with significantly reduced expression levels of inflammatory factors, matrix metalloproteinase 8, and collagen-I. The expressions of iron death-related proteins SLC7A11 and ASL4 were significantly decreased after treatment with Cur-Car-IL@Ilo hydrogel. Flora analysis showed that the content of anaerotruncus, proteus, and UCG-009 bacteria in the gut of psoriatic mice increased. The levels of paludicola, parabacteroides, prevotellaceae_UCG-001, escherichia-shigella, and aerococcus decreased, and the levels of some of the above bacteria tended to be normal after treatment. Therefore, the curcumin-based ionic liquid hydrogel can be used as a multifunctional, nonirritating, noninvasive, and highly effective percutaneous treatment of psoriasis.
银屑病是一种全身性、复发性、慢性自身免疫性皮肤病。然而，银屑病药物的皮肤渗透性差，毒性高，导致生物利用度低，影响其临床应用。在这项研究中，我们提出了一种基于姜黄素的离子液体水凝胶负载伊洛马司他（Cur-Car-IL@Ilo 水凝胶），可以有效地维持药物的持续释放并提高药物的皮肤渗透性。我们使用咪喹莫特诱导的银屑病模型，证明局部应用 Cur-Car-IL@Ilo 水凝胶可以改善小鼠的皮肤病变，显著降低炎症因子、基质金属蛋白酶 8 和胶原-I 的表达水平。用 Cur-Car-IL@Ilo 水凝胶治疗后，铁死亡相关蛋白 SLC7A11 和 ASL4 的表达明显下降。菌群分析显示，银屑病小鼠肠道中的厌氧杆菌、变形杆菌和 UCG-009 细菌含量增加。而 paludicola、parabacteroides、prevotellaceae_UCG-001、大肠杆菌-志贺氏菌和 Aerococcus 的水平降低，上述某些细菌的水平在治疗后趋于正常。因此，基于姜黄素的离子液体水凝胶可以作为一种多功能、无刺激性、非侵入性和高效的治疗银屑病的经皮治疗方法。
