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一种新型混合跨诊断干预(eOrygen)治疗青年精神病和边缘型人格障碍:非对照单组试点研究。

A Novel Blended Transdiagnostic Intervention (eOrygen) for Youth Psychosis and Borderline Personality Disorder: Uncontrolled Single-Group Pilot Study.

机构信息

Orygen, Parkville, Australia.

Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.

出版信息

JMIR Ment Health. 2024 Apr 1;11:e49217. doi: 10.2196/49217.

Abstract

BACKGROUND

Integrating innovative digital mental health interventions within specialist services is a promising strategy to address the shortcomings of both face-to-face and web-based mental health services. However, despite young people's preferences and calls for integration of these services, current mental health services rarely offer blended models of care.

OBJECTIVE

This pilot study tested an integrated digital and face-to-face transdiagnostic intervention (eOrygen) as a blended model of care for youth psychosis and borderline personality disorder. The primary aim was to evaluate the feasibility, acceptability, and safety of eOrygen. The secondary aim was to assess pre-post changes in key clinical and psychosocial outcomes. An exploratory aim was to explore the barriers and facilitators identified by young people and clinicians in implementing a blended model of care into practice.

METHODS

A total of 33 young people (aged 15-25 years) and 18 clinicians were recruited over 4 months from two youth mental health services in Melbourne, Victoria, Australia: (1) the Early Psychosis Prevention and Intervention Centre, an early intervention service for first-episode psychosis; and (2) the Helping Young People Early Clinic, an early intervention service for borderline personality disorder. The feasibility, acceptability, and safety of eOrygen were evaluated via an uncontrolled single-group study. Repeated measures 2-tailed t tests assessed changes in clinical and psychosocial outcomes between before and after the intervention (3 months). Eight semistructured qualitative interviews were conducted with the young people, and 3 focus groups, attended by 15 (83%) of the 18 clinicians, were conducted after the intervention.

RESULTS

eOrygen was found to be feasible, acceptable, and safe. Feasibility was established owing to a low refusal rate of 25% (15/59) and by exceeding our goal of young people recruited to the study per clinician. Acceptability was established because 93% (22/24) of the young people reported that they would recommend eOrygen to others, and safety was established because no adverse events or unlawful entries were recorded and there were no worsening of clinical and social outcome measures. Interviews with the young people identified facilitators to engagement such as peer support and personalized therapy content, as well as barriers such as low motivation, social anxiety, and privacy concerns. The clinician focus groups identified evidence-based content as an implementation facilitator, whereas a lack of familiarity with the platform was identified as a barrier owing to clinicians' competing priorities, such as concerns related to risk and handling acute presentations, as well as the challenge of being understaffed.

CONCLUSIONS

eOrygen as a blended transdiagnostic intervention has the potential to increase therapeutic continuity, engagement, alliance, and intensity. Future research will need to establish the effectiveness of blended models of care for young people with complex mental health conditions and determine how to optimize the implementation of such models into specialized services.

摘要

背景

将创新的数字心理健康干预措施融入专业服务中是一种很有前途的策略,可以弥补面对面和基于网络的心理健康服务的不足。然而,尽管年轻人喜欢并呼吁整合这些服务,但目前的心理健康服务很少提供混合护理模式。

目的

本试点研究测试了一种整合的数字和面对面的跨诊断干预措施(eOrygen),作为一种混合护理模式,用于治疗青年精神病和边缘型人格障碍。主要目的是评估 eOrygen 的可行性、可接受性和安全性。次要目的是评估关键临床和心理社会结局的前后变化。探索性目的是探索年轻人和临床医生在实施混合护理模式时遇到的障碍和促进因素。

方法

在澳大利亚维多利亚州墨尔本的两个青年心理健康服务机构中,共招募了 33 名年轻人(15-25 岁)和 18 名临床医生,历时 4 个月:(1)早期精神病预防和干预中心,这是一个首发精神病的早期干预服务;(2)帮助年轻人早期诊所,这是一个早期干预边缘型人格障碍的服务。通过无对照组的单一群组研究,评估了 eOrygen 的可行性、可接受性和安全性。在干预后(3 个月),采用重复测量双侧 t 检验评估临床和心理社会结局的变化。对年轻人进行了 8 次半结构定性访谈,并在干预后对 18 名临床医生中的 15 名(83%)进行了 3 次焦点小组讨论。

结果

发现 eOrygen 具有可行性、可接受性和安全性。可行性是通过低拒绝率 25%(15/59)和超出我们为每位临床医生招募研究对象的目标来确定的。可接受性是通过 93%(22/24)的年轻人表示他们会向他人推荐 eOrygen 来确定的,安全性是通过没有记录到不良事件或非法进入以及临床和社会结局测量没有恶化来确定的。与年轻人的访谈确定了一些促进因素,如同伴支持和个性化的治疗内容,以及一些障碍,如低动机、社交焦虑和隐私问题。临床医生的焦点小组确定了循证内容是实施的促进因素,而对平台不熟悉则是一个障碍,因为临床医生有其他优先事项,如对风险的关注和处理急性发作,以及人手不足的挑战。

结论

作为一种混合的跨诊断干预措施,eOrygen 有可能提高治疗的连续性、参与度、联盟和强度。未来的研究将需要确定混合护理模式对有复杂心理健康问题的年轻人的有效性,并确定如何将这些模式优化到专门服务中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3507/11019426/b1c63f60dbef/mental_v11i1e49217_fig1.jpg

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