Suppr超能文献

黑色数字至关重要:一个多专业领域的谜题。

Black Digits Matter: A Multispecialty Enigma.

作者信息

Agrawal Abhijeet, Bhagawati Jahnabi, Kumar Sunil, Acharya Sourya

机构信息

Department of Medicine, Jawaharlal Nehru Medical College, Wardha, IND.

出版信息

Cureus. 2024 Feb 28;16(2):e55133. doi: 10.7759/cureus.55133. eCollection 2024 Feb.

Abstract

Introduction Digital ischemia is alike any other visceral ischemic event leading to severe tissue damage ultimately causing necrosis of the involved extremity. It's like a preview of the upcoming systemic disorder and can present itself in any specialty and hence everyone, be it a physician or a surgeon must be primed toward how to proceed with a case of digital ischemia. In this case series, we present six such cases that presented with digital ischemic events either as a sole presentation or were followed by other systemic manifestations that led to their evaluation and ultimately the etiology behind it. Material and method Patients visiting Rheumatology OPD with complaints suggestive of digital ischemia were included in this study. All patients underwent thorough history taking and clinical examination to establish the cause of digital ischemia. Patients with probable infective, trauma, cardiac, and drug-induced causes and malignancies were excluded. As per probable autoimmune causes, patients underwent evaluation via antinuclear antibodies by immunofluorescence (ANA by IF), antiphospholipid antibodies like lupus anticoagulant (LAC), anticardiolipin antibodies (AcL) and anti Beta2GP1 antibodies, extractable nuclear antigens (ENA) and in cases of suspected vasculitis doppler ultrasound and angiography.  Results Six patients were identified as cases primarily presenting with digital ischemia or with a prior history of digital ischemia. Two patients were of the pediatric age group, one 16-year-old male presenting with acute arthritis and a history of digital ischemia one year back, and the other was a 12-year-old female with blackening of the second toe in her left foot with a history of similar complaints in the left great toe for which she underwent amputation of that toe. Other four cases were of the adult age group, with two cases of scleroderma, one with systemic lupus erythematosus, and one with Takayasu arteritis. All of these patients primarily presented to departments other than rheumatology. Conclusion Digital ischemia is a pan-specialty problem with the etiologies spreading across a vast spectrum of rheumatological disorders, many of which may present to different specialties initially, later discovered to be part of the systemic manifestation of autoimmune diseases. Hence, it becomes imperative to have a rheumatological perspective in these cases of digital ischemia which all specialities should be aware of, and timely referral may prevent permanent loss of the digits and in some cases the entire limb.

摘要

引言 手指缺血与其他任何内脏缺血事件相似,最终会导致严重的组织损伤,进而引起受累肢体坏死。它就像是即将发生的全身性疾病的一个先兆,可能出现在任何专科领域,因此,无论是内科医生还是外科医生,都必须清楚如何处理手指缺血的病例。在本病例系列中,我们呈现了6例手指缺血事件,这些病例要么仅表现为手指缺血,要么随后出现其他全身性表现,从而促使对其进行评估并最终找出病因。

材料与方法 本研究纳入了因疑似手指缺血而前来风湿科门诊就诊的患者。所有患者均接受了全面的病史采集和临床检查,以确定手指缺血的原因。排除了可能由感染、创伤、心脏疾病、药物诱导以及恶性肿瘤导致的病例。根据可能的自身免疫病因,患者通过免疫荧光法检测抗核抗体(IF法检测ANA)、抗磷脂抗体如狼疮抗凝物(LAC)、抗心磷脂抗体(AcL)和抗β2糖蛋白1抗体、可提取核抗原(ENA)进行评估,对于疑似血管炎的病例则进行多普勒超声和血管造影检查。

结果 确定了6例主要表现为手指缺血或有手指缺血病史的病例。2例为儿童年龄组,1例16岁男性,表现为急性关节炎,有1年前手指缺血的病史,另1例是12岁女性,左脚第二趾变黑,左拇趾曾有类似症状并接受了该趾截肢手术。其他4例为成人年龄组,2例为硬皮病,1例为系统性红斑狼疮,1例为大动脉炎。所有这些患者最初主要就诊于风湿科以外的科室。

结论 手指缺血是一个涉及多个专科的问题,其病因涵盖了广泛的风湿性疾病谱,其中许多疾病最初可能出现在不同专科,后来被发现是自身免疫性疾病全身性表现的一部分。因此,对于这些手指缺血病例,必须要有风湿科的视角,所有专科都应有所认识,及时转诊可能会防止手指永久性丧失,在某些情况下甚至可避免整个肢体的丧失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ac5/10979651/92f4dabf8fa4/cureus-0016-00000055133-i01.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验