Ferguson Paul B, Snavely Kennedy
Neurology, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Obstetrics and Gynecology, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Cureus. 2024 Feb 29;16(2):e55239. doi: 10.7759/cureus.55239. eCollection 2024 Feb.
Normal pressure hydrocephalus (NPH) is characterized by pathologic ventriculomegaly with normal opening pressures on lumbar puncture. It commonly presents with a triad of gait disturbance, cognitive impairment, and urinary bladder detrusor dysfunction. Its pathogenesis is complex but is thought to arise in the setting of imbalanced cerebrospinal fluid (CSF) secretion and absorption. Given that intracranial pressure often remains normal in the setting of NPH, visual symptoms are quite uncommon. Here we present a case of a 70-year-old female with a subacute history of visual aberration described as a seconds-long persistent recurrence of visual images after the stimulus was removed from the visual field in the setting of slowed and unstable gait, urinary urgency, and cognitive impairment. This patient was evaluated and ultimately diagnosed with NPH before undergoing definitive treatment with ventriculoperitoneal shunt implantation. She has shown persistent responsiveness to shunting of the CSF as manifested by sustained improvement in gait speed and stability, urinary bladder urgency, and palinopsia resolution at the six-month follow-up assessment.
正常压力脑积水(NPH)的特征是病理性脑室扩大,腰椎穿刺时开放压力正常。它通常表现为步态障碍、认知障碍和膀胱逼尿肌功能障碍三联征。其发病机制复杂,但被认为是在脑脊液(CSF)分泌和吸收失衡的情况下发生的。鉴于NPH患者颅内压通常保持正常,视觉症状相当罕见。在此,我们报告一例70岁女性病例,该患者有亚急性视觉异常病史,表现为在步态缓慢且不稳定、尿急和认知障碍的情况下,当刺激从视野中移除后,视觉图像会持续数秒反复出现。该患者在接受脑室腹腔分流术植入的确定性治疗前接受了评估并最终被诊断为NPH。在六个月的随访评估中,她对脑脊液分流持续有反应,表现为步态速度和稳定性、膀胱尿急症状持续改善以及回闪视觉症消退。