Xu Hui, Gao Yuhong, Liang Tianyu, Wang Qiqi, Wan Zhe, Li Ruoyu, Liu Wei
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.
National Clinical Research Center for Skin and Immune Diseases, Beijing, China.
Mycology. 2024 Jan 3;15(1):85-90. doi: 10.1080/21501203.2023.2299472. eCollection 2024.
Invasive aspergillosis (IA) is the most severe type of infection. Yunnan has developed agriculture, and the proportion of triazole-resistant induced by triazole fungicides is much higher than that in other regions of China. Inhalation of triazole-resistant is one of the main factors inducing IA. We gathered five strains of from the sputum or bronchoalveolar lavage fluid (BALF) of patients with IA in Yunnan. Subsequent testing showed that all of these strains were resistant to triazoles and harboured mutations in the tandem repeat sequence of the promoter region, suggesting that they may be triazole-resistant present in the environment.
侵袭性曲霉病(IA)是最严重的感染类型。云南农业发达,由三唑类杀菌剂诱导产生的三唑抗性比例远高于中国其他地区。吸入三唑抗性菌是诱发IA的主要因素之一。我们从云南IA患者的痰液或支气管肺泡灌洗(BALF)液中收集了5株菌。后续检测表明,所有这些菌株均对三唑类耐药,且在启动子区域的串联重复序列中存在突变,这表明它们可能是环境中存在的三唑抗性菌。