Wiąk-Walerowicz Katarzyna, Wielosz Ewa
Department of Rheumatology and Systemic Connective Tissue Diseases, Medical University of Lublin, Poland.
Reumatologia. 2024;62(1):64-69. doi: 10.5114/reum/185429. Epub 2024 Mar 18.
Axial spondyloarthritis (axSpA) is an inflammatory joint disease, in which the dominant symptom is inflammatory back pain. It affects approximately 1% of the population, with a higher incidence in males. Spinal pain associated with spondyloarthritis is referred to as inflammatory back pain. In clinical practice, it is extremely important to be able to assess the activity of inflammatory back diseases and to select appropriate treatment and monitor the therapy. Currently, two main tools are used for assessment of the activity of axial spondyloarthritis: BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and ASDAS (Ankylosing Spondylitis Disease Activity Score). The BASDAI is a tool used for years for assessment of disease activity, determining eligibility for treatment, and making decisions about continuation of therapy. Since BASDAI depends entirely on patient self-assessment, it is considered less objective than the ASDAS index. In turn, the latter includes not only answers to questions provided by the patient but also a parameter of inflammation such as erythrocyte sedimentation rate or C-reactive protein (CRP). Additionally, increasing numbers of studies report advantages of the ASDAS index over BASDAI. Moreover, as indicated by ASAS/EULAR (Assessment in Spondyloarthritis International Society/European Alliance of Associations for Rheumatology) 2022, ASDAS, especially ASDAS-CRP is the preferred tool for assessment of the activity of axSpA, whereas BASDAI is used only when the evaluation of the ASDAS is not possible. This paper presents the definition and symptoms of axSpA and reviews the latest research on ASDAS and BASDAI, with emphasis on the objectivity of the ASDAS assessment also presenting the doubts and limitations concerning this tool.
轴性脊柱关节炎(axSpA)是一种炎症性关节疾病,其主要症状为炎性背痛。它影响着约1%的人口,男性发病率更高。与脊柱关节炎相关的脊柱疼痛被称为炎性背痛。在临床实践中,能够评估炎性背痛疾病的活动情况、选择合适的治疗方法并监测治疗效果极为重要。目前,有两种主要工具用于评估轴性脊柱关节炎的活动情况:巴氏强直性脊柱炎疾病活动指数(BASDAI)和强直性脊柱炎疾病活动评分(ASDAS)。BASDAI多年来一直用于评估疾病活动度、确定治疗资格以及做出关于继续治疗的决策。由于BASDAI完全依赖患者自我评估,它被认为不如ASDAS指数客观。而后者不仅包括患者提供的问题答案,还包括炎症参数,如红细胞沉降率或C反应蛋白(CRP)。此外,越来越多的研究报告了ASDAS指数相对于BASDAI的优势。此外,正如国际脊柱关节炎评估协会/欧洲风湿病联盟(ASAS/EULAR)2022年所指出的,ASDAS,尤其是ASDAS-CRP是评估axSpA活动度的首选工具,而只有在无法评估ASDAS时才使用BASDAI。本文介绍了axSpA的定义和症状,并回顾了关于ASDAS和BASDAI的最新研究,重点强调了ASDAS评估的客观性,同时也介绍了关于该工具的疑问和局限性。