Suppr超能文献

一名健康女童的鼻-眶-脑毛霉菌病:病例报告

Rhino-Orbital Cerebral Mucormycosis in a Healthy Female Child: Case Report.

作者信息

Yusuf Abdisalam Abdullahi, Ibrahim Ismail Gedi, Hirsi Ibrahim Mohamed, Adali Ali, Hassan Yonis Yusuf, Yasar Mehmet Zeki, Abdullahi Ismail Mohamoud, Hassan Mohamed Sheikh

机构信息

Department of Pediatric, Mogadishu Somalia Turkish Training and Research Hospital, Mogadishu, Somalia.

Department of Radiology, Mogadishu Somalia Turkish Training and Research Hospital, Mogadishu, Somalia.

出版信息

Int Med Case Rep J. 2024 Mar 26;17:241-246. doi: 10.2147/IMCRJ.S454697. eCollection 2024.

Abstract

Mucormycosis is a potentially fatal condition with a high mortality rate, particularly when there is extra nasal involvement, and it is rare for patients with fungal brain disease to survive. It mostly affects patients who are metabolically or immunologically compromised, which constitutes one of the three classical stages of the progression of Rhino-Orbito-Cerebral Mucormycosis (ROCM). Stage I: infection of the nasal mucosa and paranasal sinuses; Stage II: orbital involvement; Stage III: cerebral involvement.Here, we report a case of rhino-orbital cerebral mucormycosis in a 14-year-old girl with no known risk factor who presented with periorbital edema, right eye proptosis, fever, and extreme facial pain, which progressively worsened to confusion and left leg weakness in 3 days after admission. The final diagnosis was rhino-orbital-cerebral mucormycosis. The infection was successfully treated using liposomal amphotericin and surgical debridement to remove infected orbital tissue. Mucormycosis is a potentially fatal disease that necessitates prompt diagnosis and treatment. Children are rarely infected with mucormycosis. The majority of studies show that people are typically between 40 and 50 years old. ROCM is typically diagnosed using clinical symptoms and histopathologic evaluation; however, imaging is critical in determining the presence of intracranial lesion. The standard treatment for ROCM is amphotericin B at a recommended dose of 1.0-1.5 mg/kg/day for weeks or months, depending on the clinical response and severity of adverse drug reactions, particularly nephrotoxicity.Rhino-orbital cerebral mucormycosis in a healthy female child is uncommon; early diagnosis and prompt treatment with Amphotericin B should be necessary. Devastating consequences will result from a delayed diagnosis.

摘要

毛霉菌病是一种潜在的致命疾病,死亡率很高,尤其是在存在鼻外受累的情况下,真菌性脑疾病患者很少能存活。它主要影响代谢或免疫功能受损的患者,这是鼻眶脑型毛霉菌病(ROCM)进展的三个经典阶段之一。第一阶段:鼻黏膜和鼻窦感染;第二阶段:眼眶受累;第三阶段:脑部受累。在此,我们报告一例14岁女孩的鼻眶脑型毛霉菌病病例,该女孩无已知危险因素,表现为眶周水肿、右眼突出、发热和极度面部疼痛,入院后3天病情逐渐恶化至意识模糊和左腿无力。最终诊断为鼻眶脑型毛霉菌病。通过脂质体两性霉素和手术清创术切除感染的眼眶组织,成功治疗了感染。毛霉菌病是一种潜在的致命疾病,需要及时诊断和治疗。儿童很少感染毛霉菌病。大多数研究表明,患者通常年龄在40至50岁之间。ROCM通常通过临床症状和组织病理学评估进行诊断;然而,影像学对于确定颅内病变的存在至关重要。ROCM的标准治疗是使用两性霉素B,推荐剂量为1.0-1.5mg/kg/天,持续数周或数月,具体取决于临床反应和药物不良反应的严重程度,尤其是肾毒性。健康女童的鼻眶脑型毛霉菌病并不常见;早期诊断并及时使用两性霉素B治疗是必要的。延迟诊断将导致灾难性后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06db/10981427/648b0ac0de93/IMCRJ-17-241-g0001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验