Leopold Todd, Gerschutz Mark, Rao Shantanu
Wood County Hospital, Bowling Green, OH, USA.
The University of Findlay, Findlay, OH, USA.
Hosp Pharm. 2023 Dec;58(6):614-620. doi: 10.1177/00185787231172389. Epub 2023 May 15.
The purpose of our study was to quantify and analyze the annual opioid usage in surgical patients at Wood County Hospital (WCH) between 2017 and 2021. : In this retrospective study, patient data between 2017 and 2021 was analyzed to determine the oral morphine milligram equivalent (MME) of opioids used in surgical patients at WCH. Annual MME prescribed per admission was compared each year using one-way ANOVA followed by Tukey post hoc test. Similarly, the annual use of intravenous (IV) acetaminophen for surgical patients per admission was also calculated and analyzed using the one-way ANOVA followed by Tukey post hoc test. : Compared to the year 2017 (42.0 ± 3.6), a statistically significant decrease in opioid usage per surgical admission (mean±SEM of MME) was observed during the years 2018 (32.6 ± 1.4; = .04), 2019 (30.4 ± 1.2; = .01), and 2021 (30.8 ± 1.9; = .01). An analysis of individual opioid use revealed a trend toward lower fentanyl and hydromorphone usage each year since 2017. A significant decrease in the annual morphine usage (mean±SEM of MME) for surgical patients was observed during both 2020 (14.4 ± 0.9; = .05) and 2021 (14.0 ± 0.7; = .05) compared to the year 2017 (22.1 ± 2.4). Finally, compared to the year 2017, a statistically significant decrease ( < .05) in the annual use of oxycodone (MME) and IV acetaminophen (mg) for pain management in surgical patients was observed from 2018 to 2021. : Our analysis reveals a significant decrease in opioid usage per surgical admission at WCH over 2017 to 2021 indicating a positive impact of the various opioid stewardship measures implemented at the hospital.
我们研究的目的是量化和分析2017年至2021年期间伍德县医院（WCH）手术患者的年度阿片类药物使用情况。在这项回顾性研究中，分析了2017年至2021年期间的患者数据，以确定WCH手术患者使用的阿片类药物的口服吗啡毫克当量（MME）。每年使用单因素方差分析（one-way ANOVA），随后进行Tukey事后检验，比较每次入院时开具的年度MME。同样，每次入院时手术患者静脉注射（IV）对乙酰氨基酚的年度使用量也进行了计算，并使用单因素方差分析，随后进行Tukey事后检验。与2017年（42.0±3.6）相比，在2018年（32.6±1.4；P = 0.04）、2019年（30.4±1.2；P = 0.01）和2021年（30.8±1.9；P = 0.01）观察到每次手术入院的阿片类药物使用量（MME的平均值±标准误）有统计学意义的下降。对个体阿片类药物使用情况的分析显示，自2017年以来，每年芬太尼和氢吗啡酮的使用量有下降趋势。与2017年（22.1±2.4）相比，在2020年（14.4±0.9；P = 0.05）和2021年（14.0±0.7；P = 0.05）均观察到手术患者年度吗啡使用量（MME的平均值±标准误）有显著下降。最后，与2017年相比，从2018年到2021年，手术患者用于疼痛管理的羟考酮（MME）和静脉注射对乙酰氨基酚（毫克）的年度使用量有统计学意义的下降（P < 0.05）。我们的分析显示，2017年至2021年期间WCH每次手术入院的阿片类药物使用量显著下降，表明医院实施的各种阿片类药物管理措施产生了积极影响。
