CXCL5基因多态性与冠状动脉侧支循环
CXCL5 gene polymorphisms and coronary collateralization.
作者信息
Keeley Ellen C, Blotner Michael R, Lipson Lewis C, Mehrad Borna
机构信息
Department of Medicine, University of Florida, Gainesville, FL, United States of America.
Division of Cardiology, University of Florida, Gainesville, FL, United States of America.
出版信息
Am Heart J Plus. 2022 Oct 17;23:100220. doi: 10.1016/j.ahjo.2022.100220. eCollection 2022 Nov.
BACKGROUND
The presence of coronary collateralization is heterogenous, even amongst those with similar degrees of epicardial coronary artery stenoses. We hypothesized that genetic variation of CXCL5, a chemokine that mediates angiogenesis, is associated with coronary collateralization.
METHODS
We genotyped subjects undergoing coronary angiography for single nucleotide polymorphisms of CXCL5 and determined the presence of spontaneously visible coronary collaterals.
RESULTS
Subjects with collaterals had less angina (46 % vs 59 %, p = 0.006), and prior percutaneous coronary intervention (34 % vs 47 %, p = 0.010), and more hyperlipidemia (90 % vs 82 %, p = 0.018), peripheral arterial disease (25 % vs 17 %, p = 0.041), congestive heart failure (16 % vs 8 %, p = 0.007), and multi-vessel coronary artery disease (41 % vs 24 %, p = 0.0001) compared to those without collaterals. Multi-vessel disease and hyperlipidemia were positive predictors of angiographically visible collaterals while being a carrier of the CXCL5 polymorphism was a negative predictor.
CONCLUSIONS
Coronary collateralization may, at least in part, be genetically determined.
背景
冠状动脉侧支循环的存在具有异质性，即使在那些心外膜冠状动脉狭窄程度相似的患者中也是如此。我们推测，介导血管生成的趋化因子CXCL5的基因变异与冠状动脉侧支循环有关。
方法
我们对接受冠状动脉造影的受试者进行CXCL5单核苷酸多态性基因分型，并确定自发可见冠状动脉侧支的存在情况。
结果
与无侧支循环的受试者相比，有侧支循环的受试者心绞痛发生率较低（46%对59%，p = 0.006），既往经皮冠状动脉介入治疗史较少（34%对47%，p = 0.010），高脂血症、外周动脉疾病、充血性心力衰竭和多支冠状动脉疾病发生率较高（高脂血症：90%对82%，p = 0.018；外周动脉疾病：25%对17%，p = 0.041；充血性心力衰竭：16%对8%，p = 0.007；多支冠状动脉疾病：41%对24%，p = 0.0001）。多支血管疾病和高脂血症是血管造影可见侧支循环的阳性预测因素，而携带CXCL5多态性是阴性预测因素。
结论
冠状动脉侧支循环可能至少部分由基因决定。
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