Wang Yang-Kun, Li Ying-Ying, Wang Bin, Ran Dong-Mei, Zhu Chao-Ya, Li Ping, Jiang Bo, Wang Su-Nan
The Fourth People"s Hospital of Longgang District, Shenzhen, 518123, China.
Shenzhen Polytechnic University, Shenzhen, 518055, China.
Heliyon. 2024 Mar 14;10(6):e27845. doi: 10.1016/j.heliyon.2024.e27845. eCollection 2024 Mar 30.
To study the histopathological staging of atrophic lesions of the gastric mucosa.
Histology and immunohistochemistry were used to closely examine 2144 specimens of atrophic gastric mucosa that were taken from endoscopic biopsies.
When the gastric mucosa epithelium is affected by infection, chemical stimulation, immune factors, genetic factors, and other factors, it may cause an atrophy of gastric mucosa epithelium and a decrease in the number of glands, intestinal metaplasia, hyperplasia of smooth muscle fibers, and atrophy of stem cells in the proliferative zone. In this study, we characterized the above lesions as atrophic lesions of the gastric mucosa. Based on the morphological and histological characteristics of the lesion, as well as the law of cell proliferation and transformation during its occurrence and development, we propose five stages. We also noted the onset age, gender correlation, and histopathological characteristics of each stage of gastric mucosal atrophies.
Understanding the pathological staging of gastric mucosal atrophy is essential for treating patients correctly and keeping track of changes in malignant cells. It is also very important in preventing the initiation of gastric cancer or from getting worse.
研究胃黏膜萎缩性病变的组织病理学分期。
采用组织学和免疫组化方法对2144例取自内镜活检的萎缩性胃黏膜标本进行仔细检查。
当胃黏膜上皮受到感染、化学刺激、免疫因素、遗传因素等影响时，可导致胃黏膜上皮萎缩、腺体数量减少、肠化生、平滑肌纤维增生以及增殖区干细胞萎缩。在本研究中，我们将上述病变特征化为胃黏膜萎缩性病变。基于病变的形态学和组织学特征，以及其发生发展过程中的细胞增殖和转化规律，我们提出了五个阶段。我们还记录了胃黏膜萎缩各阶段的发病年龄、性别相关性及组织病理学特征。
了解胃黏膜萎缩的病理分期对于正确治疗患者和追踪恶性细胞变化至关重要。在预防胃癌的发生或病情恶化方面也非常重要。
