Li Chao, Qin Jiajun, Xue Fei, Shen Zhaoli, Lin Qi, Xue Yajun, Chen Xianzhen
Department of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Neurol. 2024 Mar 15;15:1360741. doi: 10.3389/fneur.2024.1360741. eCollection 2024.
This study aimed to investigate the effects of adjuvant beam radiation therapy (ABRT) on overall survival (OS) in patients with primary single intracranial atypical meningioma (AM), with a focus on age-related outcomes.
We conducted a retrospective study using data from SEER database. Our cohort consisted of patients diagnosed with a primary single intracranial AM tumor and had undergone surgery. The primary endpoint was OS. For survival analysis, univariable and multivariable Cox regression analysis were performed. A multivariable additive Cox model was used to assess the functional relationship between age and OS in patients with or without ABRT.
Of the 2,759 patients included, 1,650 underwent gross total resection and 833 received ABRT. Multivariable Cox analysis indicated that ABRT did not significantly influence OS across the entire cohort. According to the multivariable generalized additive Cox model, the relative risk of all-cause mortality increased with advancing age in both ABRT-yes and ABRT-no group. ABRT-yes had a lower relative risk than ABRT-no when age ≤ 55 years old while a higher relative risk when age > 55 years old. Subsequent multivariable Cox analysis showed that ABRT was associated with a significant lower risk for all-cause mortality in patients with age ≤ 55 years old while a significant higher risk in patients with age > 55 years old.
Our study found that ABRT enhanced OS in younger primary single intracranial AM patients. But we also revealed a negative correlation between OS and ABRT in older patients.
本研究旨在探讨辅助束放射治疗（ABRT）对原发性单发颅内非典型脑膜瘤（AM）患者总生存期（OS）的影响，重点关注与年龄相关的结果。
我们使用监测、流行病学和最终结果（SEER）数据库的数据进行了一项回顾性研究。我们的队列包括被诊断为原发性单发颅内AM肿瘤并接受过手术的患者。主要终点是总生存期。为了进行生存分析，我们进行了单变量和多变量Cox回归分析。使用多变量加法Cox模型评估接受或未接受ABRT的患者年龄与总生存期之间的函数关系。
在纳入的2759例患者中，1650例接受了全切除，833例接受了ABRT。多变量Cox分析表明，ABRT对整个队列的总生存期没有显著影响。根据多变量广义加法Cox模型，在接受ABRT和未接受ABRT的组中，全因死亡率的相对风险均随年龄增长而增加。年龄≤55岁时，接受ABRT组的相对风险低于未接受ABRT组；而年龄>55岁时，接受ABRT组的相对风险更高。随后的多变量Cox分析表明，ABRT与年龄≤55岁患者的全因死亡率显著较低风险相关，而与年龄>55岁患者的显著较高风险相关。
我们的研究发现，ABRT可提高年轻原发性单发颅内AM患者 的总生存期。但我们也揭示了老年患者的总生存期与ABRT之间存在负相关。
