Institute of Biomedical Engineering, University of Toronto, Canada; University of Toronto - Max Planck Centre for Neural Science and Technology, University of Toronto, Canada; Krembil Brain Institute, University Health Network, Toronto, Canada.
Krembil Brain Institute, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Canada.
Neurobiol Dis. 2024 Jun 1;195:106490. doi: 10.1016/j.nbd.2024.106490. Epub 2024 Mar 30.
The auditory oddball is a mainstay in research on attention, novelty, and sensory prediction. How this task engages subcortical structures like the subthalamic nucleus and substantia nigra pars reticulata is unclear. We administered an auditory OB task while recording single unit activity (35 units) and local field potentials (57 recordings) from the subthalamic nucleus and substantia nigra pars reticulata of 30 patients with Parkinson's disease undergoing deep brain stimulation surgery. We found tone modulated and oddball modulated units in both regions. Population activity differentiated oddball from standard trials from 200 ms to 1000 ms after the tone in both regions. In the substantia nigra, beta band activity in the local field potential was decreased following oddball tones. The oddball related activity we observe may underlie attention, sensory prediction, or surprise-induced motor suppression.
听觉Oddball 范式是注意力、新奇感和感觉预测研究中的主要方法。目前尚不清楚该任务如何与丘脑底核(subthalamic nucleus)和黑质网状部(substantia nigra pars reticulata)等皮质下结构相互作用。我们对 30 名接受深部脑刺激手术的帕金森病患者的丘脑底核(subthalamic nucleus)和黑质网状部(substantia nigra pars reticulata)进行了单单元活动(35 个单元)和局部场电位(57 个记录)的记录，同时进行了听觉 Oddball 任务。我们发现两个区域都有音调调制和Oddball 调制单元。在两个区域中，群体活动在音调后 200 毫秒至 1000 毫秒之间将Oddball 与标准试验区分开来。在黑质中，局部场电位中的β频带活动在Oddball 音后减少。我们观察到的与Oddball 相关的活动可能是注意力、感觉预测或惊讶诱导的运动抑制的基础。
