Department of Biomedicine and Prevention, Interventional Radiology Unit, University of Rome Tor Vergata, Italy.
Department of Systems Medicine, Stroke Unit, University of Rome Tor Vergata, Italy.
Neuroradiol J. 2024 Aug;37(4):483-489. doi: 10.1177/19714009241242650. Epub 2024 Apr 1.
Few experiences on vertebrobasilar occlusion over underlying intracranial atherosclerotic disease have been reported in literature and the optimal strategy on how to perform a mechanical thrombectomy is unclear. The aim of this paper is to bring our experience based on patients admitted with acute vertebrobasilar occlusion with underlying atheromatous lesions.
Several data were collected from August 2009 to October 2022 including clinical history, pre- and post-treatment neurological objectivity, diagnostic images and angiographic procedural images, and clinical outcome at 6 months. We selected 13 patients from August 2009 to October 2022, 12 men and 1 woman, aged 40 to 82 years (mean age, 62.6 years).
Mechanical thrombectomy with a thromboaspiration was performed in all patients as beginning of the procedure. In three patients, the procedures resulted in excellent angiographic result and clinical outcome, while in three patients, we observed a failure of the procedural and clinical outcome. For residual intracranial stenosis in three patients, an angioplasty was performed obtaining an ischemic area related to the posterior circulation. In four patients, a stent was placed, in three patients, we obtained a good clinical outcome with a mRS between 0 and 2, while one treatment resulted in death, probably due to a late endovascular treatment.
Endovascular treatment with stent deployment appears to result in an excellent outcome in patients with occlusion of the vertebrobasilar circulation in cases of occlusion on atheromatic plaque. The degree of residual stenosis after thrombospiration can significantly affect subsequent type of treatment.
文献中鲜有关于颅内动脉粥样硬化病变基础上椎基底动脉闭塞的经验报道,如何进行机械血栓切除术的最佳策略尚不清楚。本文旨在介绍我们基于急性椎基底动脉闭塞伴动脉粥样硬化病变患者的经验。
我们收集了 2009 年 8 月至 2022 年 10 月期间的多项数据,包括临床病史、治疗前后的神经学客观指标、诊断图像和血管造影程序图像,以及 6 个月时的临床转归。我们从 2009 年 8 月至 2022 年 10 月选择了 13 名患者,男 12 例,女 1 例,年龄 40 至 82 岁(平均年龄 62.6 岁)。
所有患者均采用血栓抽吸机械血栓切除术作为治疗的开始。在 3 例患者中,手术结果显示血管造影和临床结果均非常出色,而在 3 例患者中,我们观察到手术和临床结果失败。对于 3 例患者的残余颅内狭窄,进行了血管成形术,以减轻与后循环相关的缺血区域。在 4 例患者中放置了支架,在 3 例患者中获得了 mRS 评分 0-2 的良好临床结果,而 1 例治疗结果导致死亡,可能是由于晚期血管内治疗所致。
对于椎基底动脉闭塞的患者,在动脉粥样硬化斑块基础上发生闭塞时,支架置入的血管内治疗似乎能获得出色的结果。血栓抽吸后的残余狭窄程度会显著影响后续的治疗类型。