Cerebrovascular Disease Center, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.
Department of Neurosurgery, Pudong New Area People's Hospital, 490 Chuanhuan South Road, Shanghai, 201299, China.
Cardiovasc Intervent Radiol. 2021 Dec;44(12):1954-1963. doi: 10.1007/s00270-021-02994-z. Epub 2021 Nov 5.
To evaluate the safety and efficacy of endovascular treatment (EVT) for patients with acute ischemic stroke (AIS) due to intracranial atherosclerosis-related basilar artery occlusion (ICAS-related BAO) by comparison with embolic and tandem occlusion.
We retrospectively reviewed consecutive patients with AIS due to BAO who underwent EVT. Patients were assigned to the ICAS-related group and embolic group, and tandem group based on the etiology. Baseline data, procedural details, and clinical outcomes were compared between the three groups.
A total of 100 patients (ICAS-related group: 31; embolic group: 41; tandem group: 28) were included. No significant difference was observed in the successful reperfusion (mTICI 2b or 3), but the procedural time differed significantly (60 min vs. 43 min vs. 60 min, P = 0.010). There were no differences in the different intracranial hemorrhage grades among the three groups (P = 0.134). After adjusting for baseline differences, there was no significant difference in pairwise comparisons regarding favorable outcome (mRS 0-2), moderate outcome (mRS 0-3), and mortality.
Endovascular treatment for patients with acute ICAS-related BAO had equal efficacy and safety compared with embolic BAO and tandem BAO. Primary endovascular treatment and rescue modalities were effective treatments for acute ICAS-related BAO.
通过与栓塞和串联闭塞比较,评估血管内治疗(EVT)对颅内动脉粥样硬化相关基底动脉闭塞(ICAS 相关 BAO)引起的急性缺血性脑卒中(AIS)患者的安全性和疗效。
我们回顾性分析了接受 EVT 的 AIS 患者 BAO 的连续患者。根据病因,患者被分配到 ICAS 相关组、栓塞组和串联组。比较三组之间的基线数据、手术细节和临床结果。
共纳入 100 例患者(ICAS 相关组:31 例;栓塞组:41 例;串联组:28 例)。成功再灌注(mTICI 2b 或 3)无显著差异,但手术时间有显著差异(60 分钟 vs. 43 分钟 vs. 60 分钟,P = 0.010)。三组颅内出血程度无差异(P = 0.134)。在调整基线差异后,三组之间的良好结局(mRS 0-2)、中等结局(mRS 0-3)和死亡率无显著差异。
与栓塞性 BAO 和串联性 BAO 相比,血管内治疗急性 ICAS 相关 BAO 的疗效和安全性相当。原发性血管内治疗和挽救性治疗模式是急性 ICAS 相关 BAO 的有效治疗方法。