胰岛素样生长因子-1 和胰岛素样生长因子结合蛋白-3 作为预测早产儿生长、身体成分和神经发育的早期指标。
Insulin-like growth factor-1 and insulin-like growth factor binding protein-3 as early predictors of growth, body composition, and neurodevelopment in preterm infants.
机构信息
Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Children's Minnesota, Minneapolis, MN, USA.
出版信息
J Perinatol. 2024 Nov;44(11):1617-1623. doi: 10.1038/s41372-024-01933-3. Epub 2024 Apr 1.
OBJECTIVE
To investigate the relationship between insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3) and long-term growth, body composition, and neurodevelopment in preterm infants.
STUDY DESIGN
Prospective data were collected from ≤32 weeks gestational age infant cohort (N = 50). IGF-1 and IGFBP-3 concentrations were measured at 1 week (early) and 35 weeks (late) post-menstrual age (PMA). Growth, body composition, and neurodevelopment outcomes were measured at 4 and 12 months PMA. Relationships were measured by linear regression analysis.
RESULTS
Early IGFBP-3 concentration was positively associated with neurodevelopment at 12 months PMA. Early IGF-1 concentration was positively associated with weight at 4 months PMA, head circumference at 12 months PMA, and body mass index at 12 months PMA. Late IGFBP-3 concentration was positively associated with weight at 4 months PMA.
CONCLUSION
Further investigation of these associations may lead to novel biomarkers and/or treatments to optimize health outcomes in preterm infants.
目的
研究胰岛素样生长因子 1（IGF-1）、胰岛素样生长因子结合蛋白 3（IGFBP-3）与早产儿长期生长、身体成分和神经发育的关系。
研究设计
从≤32 周胎龄婴儿队列（N=50）中收集前瞻性数据。在胎龄 1 周（早期）和 35 周（晚期）时测量 IGF-1 和 IGFBP-3 浓度。在胎龄 4 个月和 12 个月时测量生长、身体成分和神经发育结果。通过线性回归分析测量相关性。
结果
早期 IGFBP-3 浓度与 12 个月胎龄时的神经发育呈正相关。早期 IGF-1 浓度与 4 个月胎龄时的体重、12 个月胎龄时的头围和 12 个月胎龄时的体重指数呈正相关。晚期 IGFBP-3 浓度与 4 个月胎龄时的体重呈正相关。
结论
进一步研究这些相关性可能会导致新的生物标志物和/或治疗方法，以优化早产儿的健康结果。
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