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焦虑和抑郁与不宁腿综合征的关联：一项系统综述和荟萃分析。

Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis.

作者信息

An Tianyang, Sun Haiyang, Yuan Lu, Wu Xiuling, Lu Baoquan

机构信息

College of Clinical Medicine, North China University of Science and Technology, Tangshan, Hebei, China.

Cangzhou Center for Disease Control and Prevention, Cangzhou, Hebei, China.

出版信息

Front Neurol. 2024 Mar 18;15:1366839. doi: 10.3389/fneur.2024.1366839. eCollection 2024.

DOI:10.3389/fneur.2024.1366839
PMID:38562425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10982394/
Abstract

BACKGROUND

The levels of anxiety and depression among patients with restless leg syndrome (RLS) are controversial. The aim of this systematic review and meta-analysis was to compare the levels of depression and anxiety among individuals with RLS with those of healthy controls.

METHODS

We conducted an extensive electronic search of the PubMed, Web of Science, EMBASE, and Cochrane Library databases from their inception dates to 20 June 2023. Studies presenting data on depression and anxiety in individuals with RLS were included, and a comprehensive meta-analysis was performed.

RESULTS

Twenty-one studies matched the inclusion criteria. Significantly more depressive symptoms were present in the individuals with RLS than in those without RLS, as measured by the Beck Depression Inventory [mean difference (MD) = 6.58, 95% confidence interval (CI) = 5.54-7.62,  < 0.01; heterogeneity I = 0%,  = 0.99]. Similarly, the results from the Beck Anxiety Inventory indicated that there were significantly more pronounced anxiety symptoms in the individuals with RLS than in those without RLS (MD = 9.30, 95%CI = 7.65-10.94,  < 0.01; heterogeneity I = 0%,  = 0.92). The other anxiety and depression scales also yielded statistically significant results. Significant heterogeneity was observed in the Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale, with the primary contributing factor probably being the scoring criteria of the scales.

CONCLUSION

This meta-analysis found that the levels of depression and anxiety symptoms were significantly higher in individuals with RLS than in their healthy counterparts.https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023410364, (identifier CRD42023410364).

摘要

背景

不安腿综合征（RLS）患者的焦虑和抑郁水平存在争议。本系统评价和荟萃分析的目的是比较不安腿综合征患者与健康对照者的抑郁和焦虑水平。

方法

我们对PubMed、科学网、EMBASE和Cochrane图书馆数据库从创建日期至2023年6月20日进行了广泛的电子检索。纳入了呈现不安腿综合征患者抑郁和焦虑数据的研究，并进行了全面的荟萃分析。

结果

21项研究符合纳入标准。用贝克抑郁量表测量，不安腿综合征患者的抑郁症状明显多于无不安腿综合征者（平均差[MD]=6.58，95%置信区间[CI]=5.54-7.62，P<0.01；异质性I²=0%，P=0.99）。同样，贝克焦虑量表的结果表明，不安腿综合征患者的焦虑症状明显比无不安腿综合征者更明显（MD=9.30，95%CI=7.65-10.94，P<0.01；异质性I²=0%，P=0.92）。其他焦虑和抑郁量表也得出了具有统计学意义的结果。在汉密尔顿抑郁评定量表和汉密尔顿焦虑评定量表中观察到显著的异质性，主要因素可能是量表的评分标准。

结论

这项荟萃分析发现，不安腿综合征患者的抑郁和焦虑症状水平明显高于健康对照者。https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023410364，（标识符CRD42023410364）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/7cf18c1fe5b5/fneur-15-1366839-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/df8e611f92c0/fneur-15-1366839-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/ea0e0c538179/fneur-15-1366839-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/f9928d007531/fneur-15-1366839-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/a430517c2cbc/fneur-15-1366839-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/f95c2b168df5/fneur-15-1366839-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/7a556d1318d1/fneur-15-1366839-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/2db738a18c81/fneur-15-1366839-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/7cf18c1fe5b5/fneur-15-1366839-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/df8e611f92c0/fneur-15-1366839-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/ea0e0c538179/fneur-15-1366839-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/f9928d007531/fneur-15-1366839-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/a430517c2cbc/fneur-15-1366839-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/f95c2b168df5/fneur-15-1366839-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/7a556d1318d1/fneur-15-1366839-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/2db738a18c81/fneur-15-1366839-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b82/10982394/7cf18c1fe5b5/fneur-15-1366839-g008.jpg

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