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黎巴嫩精神科门诊患者中不宁腿综合征的患病率及其相关因素

Prevalence and correlates of restless leg syndrome in psychiatric outpatients in Lebanon.

作者信息

Ammar Lama A, Antoun Chadi, Nassar Joseph E, Ismail Rawan, Talih Farid R

机构信息

Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Department of Psychiatry, American University of Beirut Medical Center, Riad El Solh, PO Box 11-0236, Beirut, Lebanon.

出版信息

Sci Rep. 2025 Aug 9;15(1):29128. doi: 10.1038/s41598-025-15036-2.

Abstract

Restless Legs Syndrome (RLS) is a prevalent yet underdiagnosed neurological disorder that significantly affects quality of life. It is commonly associated with psychiatric conditions, particularly depression and anxiety. Epidemiological data on RLS prevalence among psychiatric populations are limited and virtually absent in Lebanon. This study estimated RLS prevalence among psychiatric outpatients and assessed its impact on sleep quality, daytime sleepiness, anxiety, and depression, comparing findings to international literature. In this cross-sectional study, adult psychiatric outpatients were screened using International Restless Legs Syndrome Study Group (IRLSSG) criteria. Additional questionnaires included the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Patient Health Questionnaire-9(PHQ-9), and Generalized Anxiety Disorder-7(GAD-7). Bivariate analysis compared patients with and without RLS. Multivariate regressions were utilized to adjust for potential confounders. Of 130 participants 25.4% had RLS. These patients showed significantly poorer sleep (PSQI = 11.18vs.8.10, p = 0.002), more depressive symptoms(PHQ-9 = 15.52vs.9.88,p < 0.001), and greater anxiety(GAD-7 = 15.26vs.9.51,p < 0.001), however, no significant difference was found in daytime sleepiness (ESS = 8.42vs.7.63,p = 0.405 ). RLS was significantly associated with suicidal ideation(p < 0.001). Correlation analysis revealed significant associations between RLS severity and both sleep disruption and psychiatric symptom severity. In conclusion, RLS is highly prevalent among psychiatric outpatients in Lebanon and is strongly associated with worse mental health and increased suicidal ideation.

摘要

不宁腿综合征(RLS)是一种常见但诊断不足的神经系统疾病,严重影响生活质量。它通常与精神疾病有关,尤其是抑郁症和焦虑症。关于精神疾病人群中RLS患病率的流行病学数据有限,在黎巴嫩几乎不存在。本研究估计了精神科门诊患者中RLS的患病率,并评估了其对睡眠质量、日间嗜睡、焦虑和抑郁的影响,并将研究结果与国际文献进行比较。在这项横断面研究中,使用国际不宁腿综合征研究组(IRLSSG)标准对成年精神科门诊患者进行筛查。其他问卷包括匹兹堡睡眠质量指数(PSQI)、爱泼华嗜睡量表(ESS)、患者健康问卷-9(PHQ-9)和广泛性焦虑障碍-7(GAD-7)。双变量分析比较了有和没有RLS的患者。采用多变量回归来调整潜在的混杂因素。在130名参与者中,25.4%患有RLS。这些患者的睡眠明显较差(PSQI = 11.18对8.10,p = 0.002),抑郁症状更多(PHQ-9 = 15.52对9.88,p < 0.001),焦虑程度更高(GAD-7 = 15.26对9.51,p < 0.001),然而,日间嗜睡方面没有发现显著差异(ESS = 8.42对7.63,p = 0.405)。RLS与自杀意念显著相关(p < 0.001)。相关分析显示RLS严重程度与睡眠中断和精神症状严重程度之间存在显著关联。总之,RLS在黎巴嫩精神科门诊患者中非常普遍,并且与较差的心理健康和自杀意念增加密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68d2/12334753/72039fa11895/41598_2025_15036_Fig1_HTML.jpg

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