Befrits R, Johansson C
Prostaglandins. 1985 Jan;29(1):143-52. doi: 10.1016/0090-6980(85)90159-5.
The effect of oral prostaglandin E2 (PGE2) on gastric acid secretion was examined in healthy subjects. The gastric secretion was stimulated by a modified shamfeeding procedure. Each subject underwent one control test and three tests with intragastrically administered graded doses of PGE2: 0.5, 1.0 and 2.0 mg. Oral PGE2 significantly suppressed the peak and total acid response to vagal stimulation. The total acid output in controls was 27.5 +/- 3.2 mmol/90 min and 20.8 +/- 2.8, 15.8 +/- 2.2 (p less than 0.01) and 15.9 +/- 3.8 (p less than 0.005) mmol/90 min in test series with 0.5, 1.0 and 2.0 mg PGE2 respectively. The two higher doses were equally inhibitory to an average 40%. Gastric outputs of sodium and potassium in response to modified shamfeeding were reduced by PGE2. In controls there was a significant release of plasma-gastrin in response to shamfeeding. Plasma-gastrin was apparently suppressed after the two lower doses of PGE2 but 2.0 mg PGE2 gave an elevation similar to controls. Thus the study demonstrates that oral natural PGE2 suppresses the gastric acid secretion in man. The absence of such an effect in prior studies has been one of the objections against an acid regulatory action of endogenously formed prostaglandins. The present results do not support this argument.
在健康受试者中研究了口服前列腺素E2（PGE2）对胃酸分泌的影响。采用改良假饲法刺激胃液分泌。每位受试者进行一次对照试验以及三次向胃内给予不同剂量PGE2（0.5、1.0和2.0毫克）的试验。口服PGE2显著抑制了迷走神经刺激引起的胃酸分泌峰值和总量。对照组的胃酸总分泌量为27.5±3.2毫摩尔/90分钟，在分别给予0.5、1.0和2.0毫克PGE2的试验系列中，胃酸总分泌量分别为20.8±2.8、15.8±2.2（p<0.01）和15.9±3.8（p<0.005）毫摩尔/90分钟。两个较高剂量的抑制作用相当，平均为40%。PGE2降低了改良假饲引起的钠和钾的胃分泌量。在对照组中，假饲可引起血浆胃泌素的显著释放。给予较低剂量的两种PGE2后，血浆胃泌素明显受到抑制，但2.0毫克PGE2使血浆胃泌素升高至与对照组相似的水平。因此，该研究表明口服天然PGE2可抑制人体胃酸分泌。先前研究中未发现这种作用是反对内源性前列腺素具有酸调节作用的一个理由。目前的结果不支持这一观点。
