Boquist L
Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 May 31;30(2):181-93. doi: 10.1007/BF02889101.
Parathyroid follicle formation was studied in Mongolian gerbils subjected to different concentrations of calcium in vivo and in vitro, using light and electron microscopic methods, including the potassium pyroantimonate technique and x-ray microanalysis for identification of cations. Follicles were frequent at high calcium concentration, but sparse at intermediate and low levels of calcium. Two main types of follicle were differentiated: "degenerative follicles" containing cellular debris and lined by smooth-surfaced epithelium which occasionally showed degenerative changes; and "secretory follicles" characterized by amorphous and granular contents, and an epithelium possessing microvilli and cytoplasmic projections. Amorphous masses were also seen in dilated intercellular spaces and in dilated cisterns of rough endoplasmic reticulum in the follicle epithelium. Calcium-containing precipitates were found in degenerating chief cells, and between degenerating cells and follicles. Parathyroid follicles are believed to be formed by degeneration of suppressed chief cells (degenerative follicles), and by secretion of hormonal and/or other substances into dilated intercellular spaces which progressively increase in size to form follicular cavities (secretory follicles), thereby possibly reducing the level of metabolically active parathyroid hormone. Functional suppression is believed to underlie the development of parathyroid follicles.
利用光镜和电镜方法，包括焦锑酸钾技术和X射线微分析来鉴定阳离子，在体内和体外对处于不同钙浓度环境下的蒙古沙鼠甲状旁腺滤泡形成进行了研究。高钙浓度时滤泡常见，而钙浓度处于中等和低水平时滤泡稀少。区分出了两种主要类型的滤泡：“退化滤泡”，含有细胞碎片，内衬表面光滑的上皮，偶尔会出现退化性变化；“分泌滤泡”，其特征是含有无定形和颗粒状内容物，以及具有微绒毛和细胞质突起的上皮。在滤泡上皮细胞扩张的细胞间隙和粗面内质网扩张的池内也可见到无定形物质。在退化的主细胞内，以及在退化细胞与滤泡之间发现了含钙沉淀物。甲状旁腺滤泡被认为是由受抑制的主细胞退化形成（退化滤泡），以及通过激素和/或其他物质分泌到逐渐扩大的细胞间隙中，这些细胞间隙逐渐增大形成滤泡腔（分泌滤泡）而形成，从而可能降低甲状旁腺激素的代谢活性水平。甲状旁腺滤泡的发育被认为是以功能抑制为基础的。
