Mandelli F, Martelli M, Cimino G, Alimena G, Anselmo A P, De Cuia M R, Gastaldi R, Arcese W, Papa G
Scand J Haematol. 1985 Feb;34(2):97-100. doi: 10.1111/j.1600-0609.1985.tb02240.x.
We report the case of a 38-year-old man, previously treated for Hodgkin's disease (HD) with chemo-radiotherapy who, 10 years later, developed a Burkitt lymphoma (BL) as a tumour mass of the ascendent colon and regional lymph nodes and, subsequently, on leukaemic bone-marrow cells, on the basis of histological, immunological (B phenotype, IgM-lambda) and cytogenetic, translocation t(8;14) features. The patient died a few days later; at autopsy no evidence of HD was found. This is the 2nd case of BL developing after HD so far described. The relationship between the 2 diseases is discussed and the importance of the immunodepression in the pathogenesis of the secondary Burkitt lymphoma is emphasized.
我们报告了一例38岁男性病例，该患者曾接受化疗放疗治疗霍奇金淋巴瘤（HD），10年后，在升结肠和区域淋巴结出现肿瘤肿块，随后在白血病骨髓细胞中，基于组织学、免疫学（B表型，IgM-λ）和细胞遗传学特征，发展为伯基特淋巴瘤（BL）。患者几天后死亡；尸检未发现HD迹象。这是迄今为止描述的第二例HD后发生BL的病例。讨论了两种疾病之间的关系，并强调了免疫抑制在继发性伯基特淋巴瘤发病机制中的重要性。
