[噪声性听力损失的遗传学研究进展]
[Research progress in genetics of noise-induced hearing loss].
作者信息
Li Danyang, Wang Hongyang, Wang Qiuju
机构信息
Senior Department of Otolaryngology Head and Neck Surgery，the 6th Medical Center of Chinese PLA General Hospital，Chinese PLA Medical School，Beijing，100853，China.
Nankai University School of Medicine.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Apr;38(4):343-347;353. doi: 10.13201/j.issn.2096-7993.2024.04.016.
Abstract
Noise-induced hearing loss（NIHL） is an acquired sensorineural hearing loss induced by long-term noise exposure. The susceptibility of exposed people may vary even in the same noise environment. With the development of sequencing techniques, genes related to oxidative stress, immunoinflammatory, ion homeostasis, energy metabolism, DNA damage repair and other mechanisms in NIHL have been reported continuously. And some genes may interact with noise exposure indexes. In this article, population studies on NIHL-related gene polymorphisms and gene-environment interactions in the past 20 years are reviewed, aimed to providing evidence for the construction of NIHL-related risk prediction models and the formulation of individualized interventions.
摘要
噪声性听力损失（NIHL）是一种由长期噪声暴露引起的获得性感音神经性听力损失。即使在相同的噪声环境中，受暴露人群的易感性也可能有所不同。随着测序技术的发展，与NIHL中氧化应激、免疫炎症、离子稳态、能量代谢、DNA损伤修复等机制相关的基因不断被报道。并且一些基因可能与噪声暴露指标相互作用。本文综述了过去20年中关于NIHL相关基因多态性和基因-环境相互作用的人群研究，旨在为构建NIHL相关风险预测模型和制定个体化干预措施提供证据。
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