汉族人群中 TAB2 多态性与噪声性听力损失的遗传关联研究。
Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
机构信息
School of Public Health, Southeast University, Nanjing, Jiangsu, China.
Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, Jiangsu, China.
出版信息
PLoS One. 2021 May 11;16(5):e0251090. doi: 10.1371/journal.pone.0251090. eCollection 2021.
Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.
噪声性听力损失（NIHL）是一种由各种环境和生物因素引起的常见职业病。为了研究 TAB2 与职业环境暴露人群的 NIHL 易感性之间的关系，对选定的 588 例病例和 537 例健康对照进行了遗传关联研究。对 TAB2 中的 5 个选定的单核苷酸多态性（SNP），包括 rs2744434、rs521845、rs652921、rs7896、rs9485372 进行了基因分型，在收集 DNA 样本后进行。病例组和对照组之间的参与者存在明显差异，表明携带 TAB2 的人患 NIHL 的可能性较高。结果表明，rs521845 与 NIHL 的风险密切相关，有望在未来用于诊断。
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