Department of Basic Medical Sciences, M27-122, College of Medicine, University of Sharjah, 27272, Sharjah, United Arab Emirates.
Space Medicine Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Drugs Aging. 2024 May;41(5):443-453. doi: 10.1007/s40266-024-01111-2. Epub 2024 Apr 2.
Statins medications negatively affect age-associated loss of muscle mass and strength, termed sarcopenia, and neuromuscular junction (NMJ) integrity. However, their association with the sarcopenia-related-quality-of-life (SarQoL) is unknown.
In this cross-sectional, case control study, we recruited male nonusers (n = 75 and age 75.2 ± 5.9 years) and users (n = 77 and age 77.1 ± 6.2 years) of statins to evaluate SarQoL and handgrip strength (HGS). We also measured plasma C-terminal agrin fragment-22 (CAF22) as a marker of NMJ degradation.
Statin users had higher CAF22, and lower HGS, and cumulative SarQoL scores than non-users (all p < 0.05). Plasma CAF22 exhibited negative correlations with SarQoL scores for physical and mental health, locomotion, functionality, activities-of-daily-living, and cumulative SarQoL in statins users and non-users (all p < 0.05). Lastly, the cumulative SarQoL scores exhibited positive associations with HGS and gait speed in the study participants (all p < 0.05).
Collectively, statin usage was associated with NMJ degradation and reduced SarQoL. Statins should be cautiously prescribed in patients with sarcopenia with reduced QoL.
他汀类药物会对与年龄相关的肌肉质量和力量丧失（称为肌肉减少症）以及神经肌肉接头（NMJ）的完整性产生负面影响。然而，它们与肌肉减少症相关的生活质量（SarQoL）的关系尚不清楚。
在这项横断面病例对照研究中，我们招募了未使用他汀类药物的男性（n = 75 人，年龄 75.2 ± 5.9 岁）和使用他汀类药物的男性（n = 77 人，年龄 77.1 ± 6.2 岁），以评估 SarQoL 和握力（HGS）。我们还测量了血浆 C 末端 agrin 片段-22（CAF22）作为 NMJ 降解的标志物。
与非使用者相比，他汀类药物使用者的 CAF22 更高，HGS 和累积 SarQoL 评分更低（均 p < 0.05）。血浆 CAF22 与他汀类药物使用者和非使用者的身体和心理健康、运动、功能、日常生活活动以及累积 SarQoL 的 SarQoL 评分呈负相关（均 p < 0.05）。最后，在研究参与者中，累积 SarQoL 评分与 HGS 和步态速度呈正相关（均 p < 0.05）。
他汀类药物的使用与 NMJ 降解和 SarQoL 降低有关。对于 QoL 降低的肌肉减少症患者，应谨慎开具他汀类药物。
