Zhang Xianxu, Li Shicheng, Liu Xin, Ma Zhong, Zhang Qiang, Zhang Yuji, An Jiangdong, Luo Zhiqiang
Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, 730000, P.R. China.
Orthopaedics Key Laboratory of Gansu Province, Lanzhou, Gansu, 730000, China.
J Orthop Surg Res. 2025 Jan 31;20(1):122. doi: 10.1186/s13018-025-05487-8.
Intervertebral disc degeneration (IVDD) is one of the primary causes of low back pain, significantly affecting the quality of life in the elderly population and imposing a substantial economic burden. Currently, clinical treatments for IVDD mainly focus on symptom management, with no available therapies capable of reversing or curing the disease. In recent years, statins, a class of drugs traditionally used in the treatment of cardiovascular diseases, have been shown to exert beneficial effects on IVDD through multiple mechanisms. With the advancement of research into the pleiotropic effects of statins, an increasing body of evidence suggests their potential as effective therapeutic agents for IVDD. This review summarizes the pleiotropic effects of statins and explores their potential mechanisms and actions in IVDD, with particular emphasis on changes in the expression of relevant molecular markers. Furthermore, recent advancements in the application of statins for IVDD treatment are discussed, along with the potential of combining statins with other drugs as part of multi-target therapeutic strategies. This review aims to provide a scientific reference for further investigations into the use of statins in the treatment of IVDD.
椎间盘退变（IVDD）是腰痛的主要原因之一，严重影响老年人群的生活质量，并带来巨大的经济负担。目前，IVDD的临床治疗主要集中在症状管理上，尚无能够逆转或治愈该疾病的有效疗法。近年来，他汀类药物，一类传统上用于治疗心血管疾病的药物，已被证明可通过多种机制对IVDD产生有益作用。随着对他汀类药物多效性研究的进展，越来越多的证据表明它们作为IVDD有效治疗药物的潜力。本综述总结了他汀类药物的多效性，探讨了它们在IVDD中的潜在机制和作用，特别强调了相关分子标志物表达的变化。此外，还讨论了他汀类药物在IVDD治疗应用中的最新进展，以及将他汀类药物与其他药物联合作为多靶点治疗策略一部分的潜力。本综述旨在为进一步研究他汀类药物在IVDD治疗中的应用提供科学参考。
