Révész T, Kardos G, Kajtár P, Schuler D
Cancer. 1985 Apr 15;55(8):1637-40. doi: 10.1002/1097-0142(19850415)55:8<1637::aid-cncr2820550804>3.0.co;2-h.
Between 1971 and 1981, 699 children were diagnosed to have acute lymphoblastic leukemia (ALL) in Hungary. 34 of these children had received prednisolone therapy prior to the establishment of the diagnosis. The most frequent presumptive diagnoses that prompted steroid treatment were aplastic conditions and arthritic disorders. Leukemia was diagnosed when the presenting symptoms reappeared usually several weeks after the initiation of steroid therapy and often following withdrawal of the drug. Initial leukemic burden, as judged by leukocyte count and hepatosplenomegaly, was smaller in these patients than in other children with leukemia at the time of diagnosis. Although they entered remission at the same rate as the other patients, the length of continuous complete remission was significantly shorter in the prednisolone pretreated group. It appears that prolonged prednisolone therapy given before remission induction imparts a distinct unfavorable prognosis.
1971年至1981年间，匈牙利有699名儿童被诊断患有急性淋巴细胞白血病（ALL）。其中34名儿童在确诊前接受过泼尼松龙治疗。促使进行类固醇治疗的最常见的初步诊断是再生障碍性疾病和关节炎。当通常在类固醇治疗开始几周后且经常在停药后出现的首发症状再次出现时，白血病被确诊。根据白细胞计数和肝脾肿大判断，这些患者在诊断时的初始白血病负担比其他白血病儿童要小。尽管他们与其他患者进入缓解期的速度相同，但泼尼松龙预处理组的持续完全缓解时间明显较短。似乎在诱导缓解前给予长时间的泼尼松龙治疗会带来明显不利的预后。
