Chen Pin-Yi, Keerthi Reddy T, Rajaji Umamaheswari, Alothman Asma A, Govindasamy Mani
Department of Mechanical Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan; International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City 24301, Taiwan; Department of Mechanical Engineering, Chang Gung University, Taoyuan City 33302, Taiwan.
Department of Mechanical Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan.
Ultrason Sonochem. 2024 May;105:106858. doi: 10.1016/j.ultsonch.2024.106858. Epub 2024 Mar 24.
Zinc sulfide/graphitic Carbon Nitride binary nanosheets were synthesized by using a novel sonochemical pathway with high electrocatalytic ability. The as- obtained samples were characterized by various analytical methods such as Transmission Electron Microscopy (TEM), Field emission scanning electron microscopy (FESEM), Energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction analysis (XRD), and X-ray photoelectron spectroscopy (XPS) to evaluate the properties of ZnS@CNS synthesized by this new route. Subsequently, the electrical and electrochemical performance of the proposed electrodes were characterized by using EIS and CV to establish an electroactive ability of the nanocomposites. The complete properties like structural and physical of ZnS@CNS were analyzed. As-prepared binary nanocomposite was applied towards the detection of anticancer drug (flutamide) by various electrochemical methods such as cyclic voltammetry (CV), differential pulse voltammetry (DPV) and amperometry. The glassy carbon electrode modified with a ZnS@CNS composite demonstrates a remarkable electrocatalytic efficiency for detecting flutamide in a pH 7.0 (PBS). The composite modified electrode shows synergistic effect of ZnS and CNS catalyst. The electrochemical sensing performance of the linear range was improved significantly due to high electroactive sites and rapid electron transport pathways. Crucially, the electrochemical method was successfully demonstrated in biological fluids which reveals its potential real-time applicability in the analysis of drug.
通过一种具有高电催化能力的新型超声化学途径合成了硫化锌/石墨相氮化碳二元纳米片。采用透射电子显微镜（TEM）、场发射扫描电子显微镜（FESEM）、能量色散X射线光谱（EDS）、X射线衍射分析（XRD）和X射线光电子能谱（XPS）等多种分析方法对所得样品进行表征，以评估通过这种新途径合成的ZnS@CNS的性能。随后，通过电化学阻抗谱（EIS）和循环伏安法（CV）对所制备电极的电学和电化学性能进行表征，以确定纳米复合材料的电活性能力。分析了ZnS@CNS的完整结构和物理性质。通过循环伏安法（CV）、差分脉冲伏安法（DPV）和安培法等多种电化学方法，将制备的二元纳米复合材料应用于抗癌药物（氟他胺）的检测。用ZnS@CNS复合材料修饰的玻碳电极在pH 7.0（磷酸盐缓冲液）中检测氟他胺时表现出显著的电催化效率。复合修饰电极显示出ZnS和CNS催化剂的协同效应。由于高电活性位点和快速的电子传输途径，线性范围的电化学传感性能得到显著改善。至关重要的是，该电化学方法在生物流体中得到成功验证，揭示了其在药物分析中潜在的实时适用性。
