Laboratory of Immunophysiology, GIGA Institute, Liège University, Avenue de l'Hôpital 11, 4000 Liège, Belgium; Faculty of Veterinary Medicine, Liège University, Avenue de Cureghem 5D, 4000 Liège, Belgium.
Laboratory of Immunophysiology, GIGA Institute, Liège University, Avenue de l'Hôpital 11, 4000 Liège, Belgium; Faculty of Veterinary Medicine, Liège University, Avenue de Cureghem 5D, 4000 Liège, Belgium; Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, 1300 Wavre, Belgium.
Curr Opin Virol. 2024 Jun;66:101409. doi: 10.1016/j.coviro.2024.101409. Epub 2024 Apr 2.
Influenza A virus (IAV) infections pose a global health challenge that necessitates a comprehensive understanding of the host immune response to devise effective therapeutic interventions. As monocytes and macrophages play crucial roles in host defence, inflammation, and repair, this review explores the intricate journey of these cells during and after IAV infection. First, we highlight the dynamics and functions of lung-resident macrophage populations post-IAV. Second, we review the current knowledge of recruited monocytes and monocyte-derived cells, emphasising their roles in viral clearance, inflammation, immunomodulation, and tissue repair. Third, we shed light on the consequences of IAV-induced macrophage alterations on long-term lung immunity. We conclude by underscoring current knowledge gaps and exciting prospects for future research in unravelling the complexities of macrophage responses to respiratory viral infections.
甲型流感病毒（IAV）感染对全球健康构成挑战，需要全面了解宿主对病毒的免疫反应，以制定有效的治疗干预措施。由于单核细胞和巨噬细胞在宿主防御、炎症和修复中发挥着关键作用，因此本综述探讨了这些细胞在 IAV 感染期间和之后的复杂变化过程。首先，我们强调了 IAV 感染后肺驻留巨噬细胞群体的动态和功能。其次，我们回顾了募集的单核细胞和单核细胞衍生细胞的现有知识，强调了它们在清除病毒、炎症、免疫调节和组织修复中的作用。第三，我们探讨了 IAV 诱导的巨噬细胞改变对长期肺部免疫的影响。最后，我们强调了当前研究中的知识空白，并为未来研究阐明巨噬细胞对呼吸道病毒感染的反应的复杂性提供了令人兴奋的前景。
