Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.
Brain Res. 2024 Jul 1;1834:148905. doi: 10.1016/j.brainres.2024.148905. Epub 2024 Mar 31.
Alzheimer's disease (AD) is a primary cause of dementia that affects millions of people worldwide and its prevalence is likely to increase largely in the coming decades. Multiple complex pathways, such as oxidative stress, tau and amyloid-beta (Aβ) pathology, and cholinergic dysfunction, are involved in the pathogenesis of Alzheimer's disease. The conventional treatments provide only symptomatic relief and not a complete cure for the disease. On the other hand, recent studies have looked into the possibility of flavonoids as an effective therapeutic strategy for treating AD. Quercetin, a well-known flavonol, has been extensively studied for AD treatment. Therefore, this review mainly focuses on the pharmacokinetics properties of quercetin and its modes of action, such as antioxidant, anti-inflammatory, anti-amyloidogenic, and neuroprotective properties, which are beneficial in treating AD. It also highlights the nano delivery systems of quercetin, including liposomes, nanostructures lipid carriers, solid lipid nanoparticles, nanoemulsions, microemulsions, self-emulsifying drug delivery systems, and nanoparticles reported for AD treatment. The remarkable potential of quercetin nanocarriers has been reflected in enhancing its bioavailability and therapeutic efficacy. Therefore, clinical studies must be conducted to explore it as a therapeutic strategy for Alzheimer's disease.
阿尔茨海默病（AD）是一种主要的痴呆症病因，影响着全球数以百万计的人，而且其患病率在未来几十年很可能会大幅增加。氧化应激、tau 和淀粉样蛋白-β（Aβ）病理学以及胆碱能功能障碍等多种复杂途径都参与了阿尔茨海默病的发病机制。传统的治疗方法只能提供症状缓解，而不能完全治愈这种疾病。另一方面，最近的研究已经探讨了类黄酮作为治疗 AD 的有效治疗策略的可能性。槲皮素是一种众所周知的类黄酮，已被广泛研究用于 AD 的治疗。因此，本综述主要集中讨论了槲皮素的药代动力学特性及其作用模式，如抗氧化、抗炎、抗淀粉样变性和神经保护特性，这些特性有助于治疗 AD。它还强调了槲皮素的纳米传递系统，包括用于 AD 治疗的脂质体、纳米结构脂质载体、固体脂质纳米粒、纳米乳液、微乳液、自乳化药物传递系统和纳米粒。槲皮素纳米载体的显著潜力体现在提高其生物利用度和治疗效果上。因此，必须进行临床研究，以探索其作为治疗阿尔茨海默病的治疗策略。
