Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Biomolecules. 2019 Dec 30;10(1):59. doi: 10.3390/biom10010059.
Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer's disease and its potential as a lead compound in clinical applications.
槲皮素是一种具有显著药理作用和有前途的治疗潜力的类黄酮。它广泛分布于植物中，在日常饮食中主要存在于水果和蔬菜中。槲皮素的神经保护作用已在几项体外研究中得到报道。它已被证明可以保护神经元免受氧化损伤，同时减少脂质过氧化。除了抗氧化特性外，它还抑制淀粉样β蛋白的纤维形成，阻止细胞溶解和炎症级联途径。在这篇综述中，我们概述了最近的文献，探讨了槲皮素与阿尔茨海默病认知表现之间的关系及其作为临床应用的先导化合物的潜力。
Zotero 插件
