Department of Translational Medicine, Clinical Research Centre, Lund University, Malmö, Sweden.
Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Sci Rep. 2024 Apr 2;14(1):7720. doi: 10.1038/s41598-024-58479-9.
Male reproductive impairment has been linked with an increased risk of numerous non-communicable diseases. Yet, epidemiological data on renal disease among subfertile men is scarce. Therefore, by using male childlessness as a proxy for male infertility, we aimed to investigate its association with renal function. Data was sourced from a population-based cohort including 22,444 men. After exclusion of men aged < 45 years (n = 10,842), the remaining men were divided into two groups: these being childless (n = 5494) and fathers (n = 6108). Logistic regression was applied to explore the association between male childlessness and renal impairment. Childless men as compared to fathers, were more likely to have an estimated-glomerular filtration rate < 60 ml/min/1.73m (OR 1.36, 95 CI 1.08-1.70; p = 0.008). After adjustment for age, marital status, smoking habits, diabetes, hypertension and other components of metabolic syndrome, childless men were also more likely to have dipstick proteinuria (OR 1.85, 95 CI 1.16-2.95; p = 0.01). With the growing panorama of disease associated with male reproductive impairment, men with fertility issues may constitute a target population with potential benefit from closer follow-up of their renal function.
男性生殖功能障碍与许多非传染性疾病的风险增加有关。然而，关于生育能力低下男性的肾脏疾病的流行病学数据却很少。因此，我们使用男性不育作为男性不孕的替代指标，旨在研究其与肾功能之间的关系。数据来源于一项包括 22444 名男性的基于人群的队列研究。排除年龄<45 岁的男性（n=10842）后，将其余男性分为两组：不育组（n=5494）和父亲组（n=6108）。应用逻辑回归探讨男性不育与肾功能障碍之间的关系。与父亲组相比，不育男性的肾小球滤过率估计值<60ml/min/1.73m（OR 1.36，95%CI 1.08-1.70；p=0.008）的可能性更高。在调整年龄、婚姻状况、吸烟习惯、糖尿病、高血压和代谢综合征的其他成分后，不育男性出现尿蛋白试纸阳性的可能性也更高（OR 1.85，95%CI 1.16-2.95；p=0.01）。随着与男性生殖功能障碍相关疾病的不断增多，有生育问题的男性可能构成一个目标人群，他们可能从更密切的肾功能监测中受益。
