Chen Jiaxin, Ding Zuoqi
School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.
Editorial Board of Chinese Journal of Natural Medicines, Nanjing, China.
Chin Med. 2024 Apr 3;19(1):57. doi: 10.1186/s13020-024-00928-8.
Acute promyelocytic leukemia (APL), which was once considered one of the deadliest types of leukemia, has become a curable malignancy since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) as clinical treatments. ATO, which has become the first-line therapeutic agent for APL, is derived from the natural mineral product arsenic, exemplifying an important role of natural products in the treatment of APL. Many other natural products, ranging from small-molecule compounds to herbal extracts, have also demonstrated great potential for the treatment and adjuvant therapy of APL. In this review, we summarize the natural products and representative components that have demonstrated biological activity for the treatment of APL. We also discuss future directions in better exploring their medicinal value, which may provide a reference for subsequent new drug development and combination therapy programs.
急性早幼粒细胞白血病（APL）曾被认为是最致命的白血病类型之一，自从全反式维甲酸（ATRA）和三氧化二砷（ATO）作为临床治疗药物引入以来，它已成为一种可治愈的恶性肿瘤。ATO已成为APL的一线治疗药物，它源自天然矿物质产品砷，这体现了天然产物在APL治疗中的重要作用。许多其他天然产物，从小分子化合物到草药提取物，也已显示出在APL治疗和辅助治疗方面的巨大潜力。在本综述中，我们总结了已证明具有治疗APL生物活性的天然产物和代表性成分。我们还讨论了更好地探索其药用价值的未来方向，这可能为后续的新药开发和联合治疗方案提供参考。
